chr1:11794407:T>G Detail (hg38) (MTHFR)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr1:11,854,464-11,854,464 View the variant detail on this assembly version. |
| hg38 | chr1:11,794,407-11,794,407 |
HGVS
| Type | Transcript | Protein |
|---|---|---|
| RefSeq | NM_005957.4:c.1298A>C | NP_005948.3:p.Glu433Ala |
| Ensemble | ENST00000376583.7:c.1421A>C | ENST00000376583.7:p.Glu474Ala |
| ENST00000376585.6:c.1421A>C | ENST00000376585.6:p.Glu474Ala |
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
| Score | Disease name | Description | Source | Pubmed | Links |
|---|---|---|---|---|---|
| 0.039 | Cervical Intraepithelial Neoplasia | We performed a case-control association study to evaluate the association betwee... | BeFree | 24474455 | Detail |
| 0.005 | obesity | We evaluated the relationship between polymorphisms of methylene-tetrahydrofolat... | BeFree | 17993766 | Detail |
| 0.231 | obesity | We evaluated the relationship between polymorphisms of methylene-tetrahydrofolat... | BeFree | 17993766 | Detail |
| 0.003 | obesity | We evaluated the relationship between polymorphisms of methylene-tetrahydrofolat... | BeFree | 17993766 | Detail |
| <0.001 | obesity | We evaluated the relationship between polymorphisms of methylene-tetrahydrofolat... | BeFree | 17993766 | Detail |
| <0.001 | Factor V Leiden mutation | DNA from leukocytes was tested for: factor V Leiden (mutation G1691A), factor V ... | BeFree | 19395327 | Detail |
| 0.019 | Factor V Leiden mutation | DNA from leukocytes was tested for: factor V Leiden (mutation G1691A), factor V ... | BeFree | 19395327 | Detail |
| 0.204 | rheumatoid arthritis | In this study, the six polymorphisms associated with rheumatoid arthritis (RA), ... | BeFree | 17985847 | Detail |
| 0.016 | rheumatoid arthritis | In this study, the six polymorphisms associated with rheumatoid arthritis (RA), ... | BeFree | 17985847 | Detail |
| 0.020 | rheumatoid arthritis | In this study, the six polymorphisms associated with rheumatoid arthritis (RA), ... | BeFree | 17985847 | Detail |
| 0.003 | breast carcinoma | Viable cell growth, MDI, and polymorphism frequency in MTRR (A66G and C524T) and... | BeFree | 18842997 | Detail |
| 0.017 | Malignant neoplasm of breast | Viable cell growth, MDI, and polymorphism frequency in MTRR (A66G and C524T) and... | BeFree | 18842997 | Detail |
| 0.190 | Alzheimer's disease | In this case-control study, we examined C677T and A1298C (rs1801133 and rs180113... | BeFree | 22015309 | Detail |
| 0.002 | Mental disorders | Two polymorphisms of the MTHFR gene, C677T (rs1801133) and A1298C (rs1801131), w... | BeFree | 21819229 | Detail |
| 0.008 | Huntington disease | Recently, suggestive association has been reported between a single nucleotide p... | BeFree | 16372906 | Detail |
| 0.135 | Kidney Diseases | We analyzed 821 subjects with hypertensive nephrosclerosis from the longitudinal... | BeFree | 21613384 | Detail |
| 0.009 | Malignant neoplasm of prostate | Genetic polymorphisms in MTHFR (C677T, A1298C), MTR (A2756G) and MTRR (A66G) gen... | BeFree | 23459165 | Detail |
| 0.003 | schizophrenia | Association between MTHFR C677T and A1298C, and MTRR A66G polymorphisms and susc... | BeFree | 22813657 | Detail |
| 0.006 | coronary artery disease | We studied several single nucleotide polymorphisms (SNP) in Hcy-regulating genes... | BeFree | 15612980 | Detail |
| 0.001 | colorectal cancer | This population-based case-control study was designed to investigate the interre... | BeFree | 12020105 | Detail |
| 0.148 | male infertility | We found no evidence for an association between any of these variants (MTHFR C67... | BeFree | 25578539 | Detail |
| 0.153 | Down syndrome | Therefore, we carried out a meta-analysis of 26, 17, 9, 15, 9 and 6 case-control... | BeFree | 24068460 | Detail |
| 0.040 | Down syndrome | Finally, statistically significant associations between the MTHFR A1298C and MTR... | BeFree | 17934692 | Detail |
| 0.239 | Down syndrome | Finally, statistically significant associations between the MTHFR A1298C and MTR... | BeFree | 17934692 | Detail |
| 0.007 | Coronary heart disease | We studied several single nucleotide polymorphisms (SNP) in Hcy-regulating genes... | BeFree | 15612980 | Detail |
| 0.010 | Malignant neoplasm of prostate | Genetic polymorphisms in MTHFR (C677T, A1298C), MTR (A2756G) and MTRR (A66G) gen... | BeFree | 23459165 | Detail |
| 0.006 | Down syndrome | Therefore, we carried out a meta-analysis of 26, 17, 9, 15, 9 and 6 case-control... | BeFree | 24068460 | Detail |
| 0.001 | Squamous cell carcinoma of the head and neck | Functional polymorphisms in genes encoding one-carbon metabolism enzymes, such a... | BeFree | 17596206 | Detail |
| 0.123 | male infertility | We found no evidence for an association between any of these variants (MTHFR C67... | BeFree | 25578539 | Detail |
| 0.001 | prostate carcinoma | Genetic polymorphisms in MTHFR (C677T, A1298C), MTR (A2756G) and MTRR (A66G) gen... | BeFree | 23459165 | Detail |
| <0.001 | Pregnancy Complications | This study aimed to detect the genotype distributions and allele frequencies of ... | BeFree | 25634728 | Detail |
| 0.006 | Coronary Arteriosclerosis | We studied several single nucleotide polymorphisms (SNP) in Hcy-regulating genes... | BeFree | 15612980 | Detail |
| 0.010 | Coronary heart disease | We studied several single nucleotide polymorphisms (SNP) in Hcy-regulating genes... | BeFree | 15612980 | Detail |
| 0.046 | Coronary Arteriosclerosis | We studied several single nucleotide polymorphisms (SNP) in Hcy-regulating genes... | BeFree | 15612980 | Detail |
| 0.030 | Malignant neoplasm of prostate | Genetic polymorphisms in MTHFR (C677T, A1298C), MTR (A2756G) and MTRR (A66G) gen... | BeFree | 23459165 | Detail |
| 0.006 | Coronary Arteriosclerosis | We studied several single nucleotide polymorphisms (SNP) in Hcy-regulating genes... | BeFree | 15612980 | Detail |
| 0.032 | Pregnancy Complications | This study aimed to detect the genotype distributions and allele frequencies of ... | BeFree | 25634728 | Detail |
| 0.026 | colorectal carcinoma | This population-based case-control study was designed to investigate the interre... | BeFree | 12020105 | Detail |
| 0.239 | Coronary heart disease | This meta-analysis suggests that MTR A2756G polymorphism, but not MTRR A66G and ... | BeFree | 21780915 | Detail |
| 0.024 | Down syndrome | Therefore, we carried out a meta-analysis of 26, 17, 9, 15, 9 and 6 case-control... | BeFree | 24068460 | Detail |
| 0.219 | schizophrenia | Association between MTHFR C677T and A1298C, and MTRR A66G polymorphisms and susc... | BeFree | 22813657 | Detail |
| 0.007 | Coronary heart disease | This meta-analysis suggests that MTR A2756G polymorphism, but not MTRR A66G and ... | BeFree | 21780915 | Detail |
| <0.001 | colorectal carcinoma | This population-based case-control study was designed to investigate the interre... | BeFree | 12020105 | Detail |
| 0.036 | colorectal cancer | This population-based case-control study was designed to investigate the interre... | BeFree | 12020105 | Detail |
| <0.001 | prostate carcinoma | Genetic polymorphisms in MTHFR (C677T, A1298C), MTR (A2756G) and MTRR (A66G) gen... | BeFree | 23459165 | Detail |
| 0.002 | colorectal carcinoma | This population-based case-control study was designed to investigate the interre... | BeFree | 12020105 | Detail |
| 0.239 | Coronary heart disease | We studied several single nucleotide polymorphisms (SNP) in Hcy-regulating genes... | BeFree | 15612980 | Detail |
| 0.004 | prostate carcinoma | Genetic polymorphisms in MTHFR (C677T, A1298C), MTR (A2756G) and MTRR (A66G) gen... | BeFree | 23459165 | Detail |
| 0.013 | colorectal cancer | This population-based case-control study was designed to investigate the interre... | BeFree | 12020105 | Detail |
| 0.003 | autistic disorder | A total of 138 children diagnosed as autistic based on Diagnostic and Statistica... | BeFree | 19440165 | Detail |
| 0.123 | male infertility | We found no evidence for an association between any of these variants (MTHFR C67... | BeFree | 25578539 | Detail |
| <0.001 | adult acute lymphocytic leukemia | In a case-control study, we evaluated whether four common polymorphisms in methy... | BeFree | 15159311 | Detail |
| 0.040 | Down syndrome | Therefore, we carried out a meta-analysis of 26, 17, 9, 15, 9 and 6 case-control... | BeFree | 24068460 | Detail |
| <0.001 | colorectal carcinoma | This population-based case-control study was designed to investigate the interre... | BeFree | 12020105 | Detail |
| 0.010 | coronary artery disease | We studied several single nucleotide polymorphisms (SNP) in Hcy-regulating genes... | BeFree | 15612980 | Detail |
| 0.239 | Down syndrome | Therefore, we carried out a meta-analysis of 26, 17, 9, 15, 9 and 6 case-control... | BeFree | 24068460 | Detail |
| 0.135 | coronary artery disease | We studied several single nucleotide polymorphisms (SNP) in Hcy-regulating genes... | BeFree | 15612980 | Detail |
| 0.107 | colorectal cancer | This population-based case-control study was designed to investigate the interre... | BeFree | 12020105 | Detail |
| 0.010 | Coronary heart disease | This meta-analysis suggests that MTR A2756G polymorphism, but not MTRR A66G and ... | BeFree | 21780915 | Detail |
| 0.021 | breast carcinoma | Based on the hypothesis that variants of the cSHMT C1420T together with methioni... | BeFree | 17896178 | Detail |
| 0.002 | Carcinogenesis | However, limited association is suggested between MTHFR A1298C and MS A2756G pol... | BeFree | 23864153 | Detail |
| 0.001 | Malignant tumor of cervix | No effects of MTHFR C677T polymorphism on CIN II/III risk and MTHFR A1298C or MS... | BeFree | 23864153 | Detail |
| 0.005 | breast carcinoma | Based on the hypothesis that variants of the cSHMT C1420T together with methioni... | BeFree | 17896178 | Detail |
| 0.028 | Malignant neoplasm of breast | Interaction of MTHFR C677T and A1298C, and MTR A2756G gene polymorphisms in brea... | BeFree | 23155246 | Detail |
| 0.014 | Carcinogenesis | However, limited association is suggested between MTHFR A1298C and MS A2756G pol... | BeFree | 23864153 | Detail |
| <0.001 | Thromboembolism | Methionine synthase A2756G and methylenetetrahydrofolate reductase A1298C polymo... | BeFree | 11920232 | Detail |
| <0.001 | Mild cognitive disorder | In Xinjiang Uygur subjects, the A1298C polymorphisms in MTHFR and the A2756G pol... | BeFree | 25625218 | Detail |
| 0.042 | colorectal cancer | No significant association was found between MTHFR A1298C and MTR A2756G polymor... | BeFree | 22719222 | Detail |
| 0.101 | Malignant neoplasm of breast | Interaction of MTHFR C677T and A1298C, and MTR A2756G gene polymorphisms in brea... | BeFree | 23155246 | Detail |
| 0.101 | Malignant neoplasm of breast | Based on the hypothesis that variants of the cSHMT C1420T together with methioni... | BeFree | 17896178 | Detail |
| 0.048 | Thromboembolism | Methionine synthase A2756G and methylenetetrahydrofolate reductase A1298C polymo... | BeFree | 11920232 | Detail |
| 0.003 | cervix carcinoma | No effects of MTHFR C677T polymorphism on CIN II/III risk and MTHFR A1298C or MS... | BeFree | 23864153 | Detail |
| 0.021 | breast carcinoma | Interaction of MTHFR C677T and A1298C, and MTR A2756G gene polymorphisms in brea... | BeFree | 23155246 | Detail |
| 0.005 | breast carcinoma | Interaction of MTHFR C677T and A1298C, and MTR A2756G gene polymorphisms in brea... | BeFree | 23155246 | Detail |
| 0.002 | colorectal carcinoma | No significant association was found between MTHFR A1298C and MTR A2756G polymor... | BeFree | 22719222 | Detail |
| 0.017 | Congenital Abnormality | In the group of CA of the cardiovascular system, we observed an association of M... | BeFree | 22855024 | Detail |
| 0.001 | Cervical intraepithelial neoplasia grade 2 | No effects of MTHFR C677T polymorphism on CIN II/III risk and MTHFR A1298C or MS... | BeFree | 23864153 | Detail |
| 0.136 | lymphoma | We have previously reported associations between lymphoma risk and germline poly... | BeFree | 15551285 | Detail |
| 0.028 | Malignant neoplasm of breast | Based on the hypothesis that variants of the cSHMT C1420T together with methioni... | BeFree | 17896178 | Detail |
| <0.001 | Cervical intraepithelial neoplasia grade 2 | The aim of the present meta-analysis was to determine the effects of two MTHFR (... | BeFree | 23864153 | Detail |
| 0.049 | Cardiovascular Diseases | We used the CVD-StripAssay which is based on the reverse-hybridization principle... | BeFree | 17111197 | Detail |
| 0.261 | Cardiovascular Diseases | We tested 140 with MI individuals for factor V (FV) Leiden, FV H1299R, Prothromb... | BeFree | 22752805 | Detail |
| 0.049 | Cardiovascular Diseases | We tested 140 with MI individuals for factor V (FV) Leiden, FV H1299R, Prothromb... | BeFree | 22752805 | Detail |
| 0.027 | Cardiovascular Diseases | We used the CVD-StripAssay which is based on the reverse-hybridization principle... | BeFree | 17111197 | Detail |
| 0.002 | Microalbuminuria | Analysis of the association of studied MTHFR C677T, A1298C and ACE I/D polymorph... | BeFree | 22554825 | Detail |
| 0.094 | Diabetes Mellitus, Non-Insulin-Dependent | Our study for the first time demonstrated a synergistic effect between ACE I/D w... | BeFree | 21942443 | Detail |
| 0.332 | Diabetic Nephropathy | MTHFR C677T, A1298C and ACE I/D polymorphisms as risk factors for diabetic nephr... | BeFree | 22554825 | Detail |
| 0.007 | Microalbuminuria | Analysis of the association of studied MTHFR C677T, A1298C and ACE I/D polymorph... | BeFree | 22554825 | Detail |
| 0.027 | Cardiovascular Diseases | We used the CVD-StripAssay which is based on the reverse-hybridization principle... | BeFree | 18685811 | Detail |
| 0.245 | Cardiovascular Diseases | We used the CVD-StripAssay which is based on the reverse-hybridization principle... | BeFree | 18685811 | Detail |
| 0.024 | Cardiovascular Diseases | We used the CVD-StripAssay which is based on the reverse-hybridization principle... | BeFree | 18685811 | Detail |
| 0.042 | Diabetic Nephropathy | MTHFR C677T, A1298C and ACE I/D polymorphisms as risk factors for diabetic nephr... | BeFree | 22554825 | Detail |
| 0.245 | Cardiovascular Diseases | We used the CVD-StripAssay which is based on the reverse-hybridization principle... | BeFree | 17111197 | Detail |
| 0.245 | Cardiovascular Diseases | We tested 140 with MI individuals for factor V (FV) Leiden, FV H1299R, Prothromb... | BeFree | 22752805 | Detail |
| 0.261 | Cardiovascular Diseases | We used the CVD-StripAssay which is based on the reverse-hybridization principle... | BeFree | 17111197 | Detail |
| 0.024 | Cardiovascular Diseases | We used the CVD-StripAssay which is based on the reverse-hybridization principle... | BeFree | 17111197 | Detail |
| 0.049 | Cardiovascular Diseases | We used the CVD-StripAssay which is based on the reverse-hybridization principle... | BeFree | 18685811 | Detail |
| 0.261 | Cardiovascular Diseases | We used the CVD-StripAssay which is based on the reverse-hybridization principle... | BeFree | 18685811 | Detail |
| 0.128 | Diabetes Mellitus, Non-Insulin-Dependent | Our study for the first time demonstrated a synergistic effect between ACE I/D w... | BeFree | 21942443 | Detail |
| 0.243 | Cardiovascular Diseases | We tested 140 with MI individuals for factor V (FV) Leiden, FV H1299R, Prothromb... | BeFree | 22752805 | Detail |
| 0.013 | Inflammatory Bowel Diseases | There was a statistical difference between the proportions of the mutated allele... | BeFree | 17111197 | Detail |
| 0.016 | Acute lymphocytic leukemia | C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase gene: ... | BeFree | 23183238 | Detail |
| 0.107 | colorectal cancer | Influence of methylenetetrahydrofolate reductase gene polymorphisms C677T and A1... | BeFree | 17855693 | Detail |
| <0.001 | melanoma | We evaluated genetic polymorphisms in the methylenetetrahydrofolate reductase (M... | BeFree | 16950800 | Detail |
| 0.239 | Down syndrome | Folate metabolism gene polymorphisms MTHFR C677T and A1298C and risk for Down sy... | BeFree | 23295071 | Detail |
| 0.094 | Diabetes Mellitus, Non-Insulin-Dependent | MTHFR C677T and A1298C gene polymorphisms and hyperhomocysteinemia as risk facto... | BeFree | 16828193 | Detail |
| 0.030 | liver carcinoma | Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and t... | BeFree | 17503006 | Detail |
| 0.082 | Factor V Leiden mutation | The genetic polymorphisms C677T and A1298C relating to the enzyme methylenetetra... | BeFree | 22924497 | Detail |
| 0.337 | hyperhomocysteinemia | The objectives of this study were: to determine plasma total homocysteine tHcy l... | BeFree | 16401615 | Detail |
| 0.021 | breast carcinoma | The MTHFR A1298C genotype was associated with a decreased risk of BC [OR=0.68; 9... | BeFree | 24023349 | Detail |
| 0.337 | hyperhomocysteinemia | All participants had a thrombotic workup that included the following: genetic ma... | BeFree | 23337711 | Detail |
| 0.219 | schizophrenia | Our results suggest that deficient MTHFR enzyme activity in pregnant women, rela... | BeFree | 20044984 | Detail |
| 0.146 | Homocysteinemia | MTHFR C677T and A1298C gene polymorphisms and hyperhomocysteinemia as risk facto... | BeFree | 16828193 | Detail |
| 0.146 | Homocysteinemia | The fact that MTHFR A1298C polymorphism is significantly associated with homocys... | BeFree | 16244782 | Detail |
| <0.001 | Skin toxicity | MTHFR A1298C polymorphism was found to be associated with decreased risk of skin... | BeFree | 22528943 | Detail |
| 0.023 | thrombophilia | The authors used polymerase chain reaction (PCR) measures for thrombophilia (FVL... | BeFree | 18796459 | Detail |
| 0.004 | esophageal carcinoma | Genetic polymorphism of MTHFR A1298C and esophageal cancer susceptibility: a met... | BeFree | 23679298 | Detail |
| 0.216 | thrombophilia | The authors used polymerase chain reaction (PCR) measures for thrombophilia (FVL... | BeFree | 18796459 | Detail |
| 0.135 | coronary artery disease | A1298C methylenetetrahydrofolate reductase mutation and coronary artery disease:... | BeFree | 12049191 | Detail |
| 0.004 | Carcinoma of bladder | MTHFR C677T and A1298C polymorphisms were associated with bladder cancer risk an... | BeFree | 23578207 | Detail |
| 0.037 | melanoma | We evaluated genetic polymorphisms in the methylenetetrahydrofolate reductase (M... | BeFree | 16950800 | Detail |
| 0.204 | rheumatoid arthritis | Methotrexate related adverse effects in patients with rheumatoid arthritis are a... | BeFree | 15361376 | Detail |
| 0.337 | hyperhomocysteinemia | A thrombophilic evaluation was performed, revealing hyperhomocysteinemia and met... | BeFree | 24923843 | Detail |
| 0.001 | Adenocarcinoma Of Esophagus | Association of methylenetetrahydrofolate reductase C677T-A1298C polymorphisms wi... | BeFree | 21951971 | Detail |
| 0.021 | breast carcinoma | Interactions between MTHFR C677T-A1298C variants and folic acid deficiency affec... | BeFree | 22901194 | Detail |
| 0.002 | Glaucoma, Primary Open Angle | To investigate the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C ... | BeFree | 19936026 | Detail |
| 0.026 | Activated Protein C Resistance | We detected methylenetetrahydrofolate reductase (MTHFR) A1298C, MTHFR C677T, fac... | BeFree | 20868443 | Detail |
| 0.016 | Acute lymphocytic leukemia | Methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms and ther... | BeFree | 19391036 | Detail |
| <0.001 | Experimental Organism Basal Cell Carcinoma | We evaluated genetic polymorphisms in the methylenetetrahydrofolate reductase (M... | BeFree | 16950800 | Detail |
| 0.063 | Kidney Failure, Chronic | Effect of the MTHFR C677T and A1298C polymorphisms on survival in patients with ... | BeFree | 19272686 | Detail |
| 0.146 | Homocysteinemia | The objectives of this study were: to determine plasma total homocysteine tHcy l... | BeFree | 16401615 | Detail |
| 0.155 | Vascular Diseases | C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase gene: ... | BeFree | 11274015 | Detail |
| 0.004 | Activated Protein C Resistance | All 11 cases had one or more familial thrombophilic coagulation disorder includi... | BeFree | 16015408 | Detail |
| 0.204 | rheumatoid arthritis | Associations between the C677T and A1298C polymorphisms of MTHFR and the efficac... | BeFree | 20067328 | Detail |
| 0.016 | Acute lymphocytic leukemia | A meta-analysis of MTHFR C677T and A1298C polymorphisms and risk of acute lympho... | BeFree | 21495160 | Detail |
| 0.004 | prostate carcinoma | The analysis of the relationship between A1298C and C677T polymorphisms of the M... | BeFree | 19814618 | Detail |
| 0.057 | Malignant neoplasm of lung | Meta-analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymo... | BeFree | 18789576 | Detail |
| 0.046 | Coronary Arteriosclerosis | Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA275... | BeFree | 16268464 | Detail |
| 0.107 | colorectal cancer | Association of polymorphisms MTHFR C677T and A1298C with risk of colorectal canc... | BeFree | 19669769 | Detail |
| 0.046 | Coronary Arteriosclerosis | We investigated the influence of elevated homocysteine plasma levels and 2 polym... | BeFree | 14604831 | Detail |
| 0.094 | Diabetes Mellitus, Non-Insulin-Dependent | This study aimed to investigate the influence of the C677T and A1298C polymorphi... | BeFree | 12897091 | Detail |
| 0.101 | Malignant neoplasm of breast | Lack of association between methylenetetrahydrofolate reductase gene A1298C poly... | BeFree | 21052845 | Detail |
| 0.003 | essential hypertension | Association between methylenetetrahydrofolate reductase (MTHFR) C677T/A1298C pol... | BeFree | 25458833 | Detail |
| 0.004 | Adenoma of large intestine | MTHFR (C677T and A1298C) polymorphisms and risk of sporadic distal colorectal ad... | BeFree | 16783607 | Detail |
| 0.004 | Cleft lip with or without cleft palate | MTHFR 677TT alone and IRF6 820GG together with MTHFR 677CT, but not MTHFR A1298C... | BeFree | 19419265 | Detail |
| 0.003 | Unipolar Depression | The authors performed a meta-analysis of studies examining the association betwe... | BeFree | 17074966 | Detail |
| 0.001 | Lymphoma, Large-Cell, Follicular | The aim of our study was to investigate the potential influence of the C677T and... | BeFree | 23488607 | Detail |
| 0.017 | Inflammatory Bowel Diseases | There was a statistical difference between the proportions of the mutated allele... | BeFree | 17111197 | Detail |
| 0.003 | prothrombin gene mutation | In 118 infants with clinical signs of NE following perinatal HI, thrombophilic f... | BeFree | 23128422 | Detail |
| <0.001 | Oral Cavity Carcinoma | Polymorphisms of MTHFR C677T and A1298C association with oral carcinoma risk: a ... | BeFree | 22536935 | Detail |
| 0.047 | Factor V Leiden mutation | The genetic polymorphisms C677T and A1298C relating to the enzyme methylenetetra... | BeFree | 22924497 | Detail |
| 0.094 | Diabetes Mellitus, Non-Insulin-Dependent | The frequency of two MTHFR mutations, a recently described mutation in the human... | BeFree | 11015479 | Detail |
| 0.016 | Acute lymphocytic leukemia | The aim of the present study was to determine the role of the two most common po... | BeFree | 22017305 | Detail |
| <0.001 | melanoma | We evaluated genetic polymorphisms in the methylenetetrahydrofolate reductase (M... | BeFree | 16950800 | Detail |
| 0.003 | Unipolar Depression | This study shows that CC genotype of the MTHFR A1298C is associated with higher ... | BeFree | 23255668 | Detail |
| 0.021 | multiple myeloma | Gene microarray was used to detect MTHFR C677T and A1298C single nucleotide poly... | BeFree | 24839819 | Detail |
| 0.001 | squamous cell carcinoma | We evaluated genetic polymorphisms in the methylenetetrahydrofolate reductase (M... | BeFree | 16950800 | Detail |
| 0.144 | lymphoma | C677T and A1298C methylenetetrahydrofolate reductase (MTHFR) polymorphisms have ... | BeFree | 14535593 | Detail |
| 0.005 | kidney failure | Effect of the MTHFR C677T and A1298C polymorphisms on survival in patients with ... | BeFree | 19272686 | Detail |
| 0.008 | Malignant tumor of colon | Recently, methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) mutations... | BeFree | 16886608 | Detail |
| 0.002 | Ovarian Diseases | Our results showed the significance of MTHFR A1298C and PAI-1 4G/5G mutations in... | BeFree | 22882325 | Detail |
| 0.064 | Folic Acid Deficiency | MTHFR A1298C polymorphism reduces the enzymatic activity and mimics as folate de... | BeFree | 24970119 | Detail |
| 0.003 | early pregnancy | The methylenetetrahydrofolate reductase (MTHFR) gene C677T and A1298C polymorphi... | BeFree | 11938441 | Detail |
| 0.001 | Non-alcoholic Fatty Liver Disease | The aim of this study was to investigate the relation between liver steatosis wi... | BeFree | 23547829 | Detail |
| 0.137 | Lymphoma, Non-Hodgkin | Association of MTHFR C677T and A1298C polymorphisms with non-Hodgkin lymphoma su... | BeFree | 25146845 | Detail |
| 0.020 | Myeloid Leukemia, Chronic | We conducted a case-control study analyzing the prevalence of the polymorphisms ... | BeFree | 22576927 | Detail |
| 0.146 | Homocysteinemia | MTHFR polymorphisms C677T and A1298C are associated with reduced MTHFR enzyme ac... | BeFree | 22377704 | Detail |
| <0.001 | Hereditary Nonpolyposis Colorectal Cancer | Influence of methylenetetrahydrofolate reductase gene polymorphisms C677T and A1... | BeFree | 17855693 | Detail |
| <0.001 | Lesion of brain | APS, revealed by anti-beta-2-glycoprotein and anti-prothrombin antibodies positi... | BeFree | 16595601 | Detail |
| 0.016 | Acute lymphocytic leukemia | We conducted a case-control study in 95 north Indian children with acute lymphob... | BeFree | 20367562 | Detail |
| 0.137 | Lymphoma, Non-Hodgkin | This is the first reported case of intracardiac thrombosis with MTHFR A1298C and... | BeFree | 18432505 | Detail |
| 0.010 | cervix carcinoma | Association between MTHFR C677T, MTHFR A1298C and MS A2756G polymorphisms and ri... | BeFree | 23864153 | Detail |
| 0.032 | Pregnancy Complications | The aim of our study was to examine the association of selected thrombophilic po... | BeFree | 25549181 | Detail |
| 0.148 | male infertility | Association of the MTHFR A1298C variant with unexplained severe male infertility... | BeFree | 22457816 | Detail |
| 0.219 | schizophrenia | Association of the C677T and A1298C polymorphisms of methylenetetrahydrofolate r... | BeFree | 16084002 | Detail |
| 0.042 | Diabetic Nephropathy | The association between two common mutations C677T and A1298C in human methylene... | BeFree | 11015479 | Detail |
| 0.216 | thrombophilia | Placenta slides of 65 IUFDs with known maternal thrombophilia test results (comp... | BeFree | 22173239 | Detail |
| 0.146 | Homocysteinemia | Hyperhomocysteinemia is considered an independent risk factor for liver diseases... | BeFree | 24051448 | Detail |
| 0.026 | colorectal carcinoma | Certain common polymorphisms within the MTHFR gene (C677T, A1298C) result in red... | BeFree | 18804702 | Detail |
| 0.107 | colorectal cancer | Different roles of MTHFR C677T and A1298C polymorphisms in colorectal adenoma an... | BeFree | 17089070 | Detail |
| 0.003 | polyps | We examined the relationship between MTHFR C677T and A1298C gene polymorphisms a... | BeFree | 16783607 | Detail |
| 0.002 | Thrombosis of cerebral veins | Role of methylenetetrahydrofolate reductase A1298C polymorphism in cerebral veno... | BeFree | 23314385 | Detail |
| 0.006 | Malignant tumor of cervix | Association between MTHFR C677T, MTHFR A1298C and MS A2756G polymorphisms and ri... | BeFree | 23864153 | Detail |
| 0.007 | Central Nervous System Neoplasms | We found that the homozygous CC allele of MTHFR A1298C conferred an increased ri... | BeFree | 18406541 | Detail |
| 0.107 | colorectal cancer | We aimed to test the hypothesis that C677T and A1298C variants of MTHFR predispo... | BeFree | 20193847 | Detail |
| 0.021 | Myeloid Leukemia, Chronic | Gene microarray was used to detect MTHFR C677T and A1298C single nucleotide poly... | BeFree | 24839819 | Detail |
| 0.046 | Coronary Arteriosclerosis | Homocysteine and methylenetetrahydrofolate reductase C677T and A1298C polymorphi... | BeFree | 18204887 | Detail |
| <0.001 | Renal sclerosis with hypertension | We conclude that the MTHFR-coding polymorphism at A1298C is associated with rena... | BeFree | 21613384 | Detail |
| 0.010 | cervix carcinoma | MTHFR C677T and A1298C polymorphisms and cervical carcinoma susceptibility: meta... | BeFree | 22711309 | Detail |
| 0.004 | melanoma | We evaluated genetic polymorphisms in the methylenetetrahydrofolate reductase (M... | BeFree | 16950800 | Detail |
| 0.135 | coronary artery disease | We investigated the influence of elevated homocysteine plasma levels and 2 polym... | BeFree | 14604831 | Detail |
| 0.016 | Metabolic syndrome X | Subjects were screened for the metabolic syndrome (National Cholesterol Educatio... | BeFree | 22370993 | Detail |
| <0.001 | Malignant neoplasm of skin | We evaluated genetic polymorphisms in the methylenetetrahydrofolate reductase (M... | BeFree | 16950800 | Detail |
| 0.003 | Erectile dysfunction | Role of methylenetetrahydrofolate reductase gene polymorphisms (C677T, A1298C, a... | BeFree | 21044744 | Detail |
| 0.337 | hyperhomocysteinemia | Screening for C677T and A1298C MTHFR polymorphisms in patients with epilepsy and... | BeFree | 15970629 | Detail |
| 0.001 | Chronic Kidney Diseases | Effect of the MTHFR C677T and A1298C polymorphisms on survival in patients with ... | BeFree | 19272686 | Detail |
| 0.005 | colon carcinoma | Recently, methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) mutations... | BeFree | 16886608 | Detail |
| 0.002 | THROMBOPHILIA DUE TO ACTIVATED PROTEIN C RESISTANCE (disorder) | We detected methylenetetrahydrofolate reductase (MTHFR) A1298C, MTHFR C677T, fac... | BeFree | 20868443 | Detail |
| 0.337 | hyperhomocysteinemia | MTHFR polymorphisms C677T and A1298C are associated with reduced MTHFR enzyme ac... | BeFree | 22377704 | Detail |
| 0.146 | Homocysteinemia | to investigate if NAFLD, in subjects referred for nutritional assessment and cou... | BeFree | 24488901 | Detail |
| 0.146 | Homocysteinemia | Hyperhomocysteinemia causes steatosis, and the methylenetetrahydrofolate reducta... | BeFree | 17563923 | Detail |
| 0.239 | Coronary heart disease | Because the fetus is lost in a great proportion of trisomy 21 pregnancies, both ... | BeFree | 21159028 | Detail |
| 0.003 | Prothrombin G20210A mutation | No significant associations between the groups were found when samples were anal... | BeFree | 22924497 | Detail |
| 0.146 | Homocysteinemia | The proband's 69-year-old father, with NAION and ischemic stroke, had PTG hetero... | BeFree | 18796459 | Detail |
| 0.107 | colorectal cancer | Certain common polymorphisms within the MTHFR gene (C677T, A1298C) result in red... | BeFree | 18804702 | Detail |
| 0.017 | Congenital Abnormality | The methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms a... | BeFree | 18452180 | Detail |
| 0.137 | Lymphoma, Non-Hodgkin | Methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms and ther... | BeFree | 19391036 | Detail |
| 0.257 | Cerebrovascular accident | Pediatric stroke and methylenetetrahydrofolate reductase polymorphisms: an exami... | BeFree | 16282888 | Detail |
| 0.022 | osteoporosis | The examined SNPs (MTHFR (C677T, and A1298C), TGFβ1 (T869C), and TNFB (A252G)) w... | BeFree | 25981594 | Detail |
| 0.003 | Rectal Carcinoma | These results in the present study suggested that polymorphisms of the MTHFR C67... | BeFree | 18712959 | Detail |
| 0.337 | hyperhomocysteinemia | Compound heterozygosity for the C677T and A1298C mutations of the MTHFR gene in ... | BeFree | 19366086 | Detail |
| 0.146 | Homocysteinemia | The MTHFR polymorphism (C677T and A1298C) resulted in different outcomes regardi... | BeFree | 23108747 | Detail |
| 0.030 | Malignant neoplasm of prostate | Relationship between three polymorphisms of methylenetetrahydrofolate reductase ... | BeFree | 20564317 | Detail |
| 0.005 | Non-small cell lung carcinoma | Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms in patie... | BeFree | 12883704 | Detail |
| 0.146 | Homocysteinemia | All participants had a thrombotic workup that included the following: genetic ma... | BeFree | 23337711 | Detail |
| 0.042 | Diabetic Nephropathy | Relationship between methylenetetrahydrofolate reductase (MTHFR) A1298C gene pol... | BeFree | 24678913 | Detail |
| 0.232 | Precursor Cell Lymphoblastic Leukemia Lymphoma | The effect of RFC G80A polymorphism in Cretan children with acute lymphoblastic ... | BeFree | 24237708 | Detail |
| <0.001 | Diplegia | MTHFR A1298C (heterozygous) was associated with a reduced risk of diplegia devel... | BeFree | 16202738 | Detail |
| 0.006 | Mental Retardation | Lack of association between MTHFR C677T and MTHFR A1298C genetic polymorphisms a... | BeFree | 18782485 | Detail |
| 0.057 | Malignant neoplasm of lung | Our meta-analysis supports that the common polymorphisms of C677T and A1298C in ... | BeFree | 22215214 | Detail |
| 0.082 | Factor V Leiden mutation | Plasma homocysteine, vitamin B12, folate, creatinine, and protein C levels were ... | BeFree | 20935614 | Detail |
| 0.239 | Down syndrome | MTHFR C677T and A1298C polymorphisms as a risk factor for congenital heart defec... | BeFree | 21159028 | Detail |
| 0.005 | acute leukemia | The MTHFR C677T and A1298C polymorphisms are not significant risk factors in adu... | BeFree | 17970089 | Detail |
| 0.016 | Acute lymphocytic leukemia | Methylenetetrahydrofolate reductase A1298C genotypes are associated with the ris... | BeFree | 16706930 | Detail |
| 0.026 | colorectal carcinoma | Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and colorecta... | BeFree | 15546509 | Detail |
| 0.006 | Blood Coagulation Disorders | All 11 cases had one or more familial thrombophilic coagulation disorder includi... | BeFree | 16015408 | Detail |
| 0.008 | Angle Closure Glaucoma | MTHFR gene C677T and A1298C polymorphisms and homocysteine levels in primary ope... | BeFree | 19936026 | Detail |
| 0.008 | oligospermia | The objective of this study was to analyze the distribution of the methylenetetr... | BeFree | 21138341 | Detail |
| 0.204 | rheumatoid arthritis | A1298C polymorphism in the MTHFR gene predisposes to cardiovascular risk in rheu... | BeFree | 20423475 | Detail |
| 0.032 | Pregnancy Complications | We identified the carriage of the MTHFR A1298C polymorphism as a significant ris... | BeFree | 21577095 | Detail |
| 0.026 | colorectal carcinoma | Different roles of MTHFR C677T and A1298C polymorphisms in colorectal adenoma an... | BeFree | 17089070 | Detail |
| 0.012 | Fatty Liver | The aim of this study was to investigate the relation between liver steatosis wi... | BeFree | 23547829 | Detail |
| 0.239 | Coronary heart disease | Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA275... | BeFree | 16268464 | Detail |
| 0.163 | Colonic Neoplasms | We investigated 2 polymorphisms in the MTHFR gene (C677T and A1298C) and their a... | BeFree | 16177213 | Detail |
| 0.013 | stomach carcinoma | Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric c... | BeFree | 25170232 | Detail |
| 0.015 | Diabetes Mellitus, Insulin-Dependent | The objectives of this study were: to determine plasma total homocysteine tHcy l... | BeFree | 16401615 | Detail |
| 0.029 | Ischemic stroke | Methylenetetrahydrofolate reductase (C677T and A1298C) polymorphisms, hyperhomoc... | BeFree | 23642756 | Detail |
| 0.239 | Coronary heart disease | We investigated the influence of elevated homocysteine plasma levels and 2 polym... | BeFree | 14604831 | Detail |
| 0.159 | Precursor Cell Lymphoblastic Leukemia Lymphoma | Most studies found a strong association between the polymorphisms MTHFR, C677T o... | BeFree | 17023046 | Detail |
| 0.007 | Carcinoma of lung | Meta-analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymo... | BeFree | 18789576 | Detail |
| 0.011 | prothrombin gene mutation | In 118 infants with clinical signs of NE following perinatal HI, thrombophilic f... | BeFree | 23128422 | Detail |
| 0.239 | Down syndrome | Methylenetetrahydrofolate reductase polymorphisms C677T and A1298C as maternal r... | BeFree | 21198396 | Detail |
| 0.032 | Malignant neoplasm of urinary bladder | MTHFR C677T and A1298C polymorphisms were associated with bladder cancer risk an... | BeFree | 23578207 | Detail |
| 0.042 | Diabetic Nephropathy | MTHFR C677T and A1298C gene polymorphisms and hyperhomocysteinemia as risk facto... | BeFree | 16828193 | Detail |
| 0.232 | Precursor Cell Lymphoblastic Leukemia Lymphoma | Certain common polymorphisms within the MTHFR gene (C677T, A1298C) result in red... | BeFree | 18804702 | Detail |
| 0.025 | Anemia, Sickle Cell | Association of the methylenetetrahydrofolate reductase A1298C but not the C677T ... | BeFree | 16987799 | Detail |
| 0.107 | colorectal cancer | Methylenetetrahydrofolate reductase gene germ-line C677T and A1298C SNPs are ass... | BeFree | 25292054 | Detail |
| 0.003 | essential tremor | Association of the C677T and A1298C polymorphisms of methylenetetrahydrofolate r... | BeFree | 15390052 | Detail |
| 0.026 | colorectal carcinoma | C677T and A1298C mutations in the MTHFR gene and survival in colorectal cancer. | BeFree | 20076818 | Detail |
| 0.168 | congenital heart defects | Evaluation of C677T and A1298C polymorphisms of the MTHFR gene as maternal risk ... | BeFree | 19725133 | Detail |
| 0.001 | Activated Protein C Resistance | We detected methylenetetrahydrofolate reductase (MTHFR) A1298C, MTHFR C677T, fac... | BeFree | 20868443 | Detail |
| 0.046 | Coronary Arteriosclerosis | Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms, plasma ... | BeFree | 15135689 | Detail |
| 0.046 | Coronary Arteriosclerosis | Methylenetetrahydrofolate reductase gene, homocysteine and coronary artery disea... | BeFree | 18384842 | Detail |
| 0.032 | Malignant neoplasm of urinary bladder | However, patients heterozygous for MTHFR A1298C or MTR A2756 G genotypes have 1.... | BeFree | 19837268 | Detail |
| 0.064 | Folic Acid Deficiency | Interactions between MTHFR C677T-A1298C variants and folic acid deficiency affec... | BeFree | 22901194 | Detail |
| 0.026 | colorectal carcinoma | Influence of methylenetetrahydrofolate reductase gene polymorphisms C677T and A1... | BeFree | 17855693 | Detail |
| 0.204 | rheumatoid arthritis | Association of the MTHFR C677T and A1298C polymorphisms with methotrexate toxici... | BeFree | 24794492 | Detail |
| 0.082 | Factor V Leiden mutation | In a total of 543 Turkish women with RPL and 327 of their male partners (870 ind... | BeFree | 22047507 | Detail |
| 0.013 | stomach carcinoma | Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A... | BeFree | 18162478 | Detail |
| 0.168 | congenital heart defects | Association between 5,10-methylenetetrahydrofolate reductase C677T and A1298C po... | BeFree | 12705333 | Detail |
| 0.121 | orofacial cleft 1 | Two common MTHFR gene polymorphisms (C677T and A1298C) have been implicated in t... | BeFree | 23692788 | Detail |
| <0.001 | Lesion of brain | APS, revealed by anti-beta-2-glycoprotein and anti-prothrombin antibodies positi... | BeFree | 16595601 | Detail |
| 0.204 | rheumatoid arthritis | Polymorphisms C677T and A1298C in the MTHFR gene in Mexican patients with rheuma... | BeFree | 20514079 | Detail |
| 0.045 | spina bifida | Methylenetetrahydrofolate reductase (MTHFR): incidence of mutations C677T and A1... | BeFree | 12707953 | Detail |
| <0.001 | Lesion of brain | APS, revealed by anti-beta-2-glycoprotein and anti-prothrombin antibodies positi... | BeFree | 16595601 | Detail |
| 0.004 | Acute lymphocytic leukemia | Most studies found a strong association between the polymorphisms MTHFR, C677T o... | BeFree | 17023046 | Detail |
| 0.337 | hyperhomocysteinemia | Hyperhomocysteinemia is considered an independent risk factor for liver diseases... | BeFree | 24051448 | Detail |
| 0.029 | Ischemic stroke | In conclusion, the C677T and A1298C polymorphisms of the MTHFR gene are genetic ... | BeFree | 17113927 | Detail |
| 0.003 | THROMBOPHILIA DUE TO ACTIVATED PROTEIN C RESISTANCE (disorder) | We detected methylenetetrahydrofolate reductase (MTHFR) A1298C, MTHFR C677T, fac... | BeFree | 20868443 | Detail |
| 0.004 | congenital heart disease | MTHFR C677T and A1298C gene polymorphisms and their relation to homocysteine lev... | BeFree | 23933414 | Detail |
| 0.239 | Coronary heart disease | Homocysteine and methylenetetrahydrofolate reductase C677T and A1298C polymorphi... | BeFree | 18204887 | Detail |
| 0.107 | colorectal cancer | Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and colorecta... | BeFree | 15546509 | Detail |
| 0.245 | Cardiovascular Diseases | The common mutations C677T and A1298C in the human methylenetetrahydrofolate red... | BeFree | 12187094 | Detail |
| 0.003 | adult acute lymphocytic leukemia | Association of the 5,10-methylenetetrahydrofolate reductase (MTHFR C677T and A12... | BeFree | 17970089 | Detail |
| 0.216 | thrombophilia | The case with factor VIII of 160% had two other thrombophilias (compound MTHFR C... | BeFree | 16015408 | Detail |
| 0.013 | stomach carcinoma | Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric c... | BeFree | 20470942 | Detail |
| 0.146 | Homocysteinemia | We investigated whether the MTHFR C677T and A1298C polymorphisms contribute to h... | BeFree | 16629766 | Detail |
| 0.239 | Coronary heart disease | Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms, plasma ... | BeFree | 15135689 | Detail |
| 0.002 | Carcinoma of bladder | However, patients heterozygous for MTHFR A1298C or MTR A2756 G genotypes have 1.... | BeFree | 19837268 | Detail |
| 0.004 | prostate carcinoma | Relationship between three polymorphisms of methylenetetrahydrofolate reductase ... | BeFree | 20564317 | Detail |
| 0.004 | Cancer of Head and Neck | No association between MTHFR A1298C gene polymorphism and head and neck cancer r... | BeFree | 23098497 | Detail |
| 0.232 | Precursor Cell Lymphoblastic Leukemia Lymphoma | The aim of the present study was to determine the role of the two most common po... | BeFree | 22017305 | Detail |
| 0.004 | Homocysteinemia | All participants had a thrombotic workup that included the following: genetic ma... | BeFree | 23337711 | Detail |
| 0.005 | colon carcinoma | Using data from an incident case-control study (1608 cases and 1972 controls) we... | BeFree | 14973104 | Detail |
| 0.015 | Ischemic Cerebrovascular Accident | In conclusion, the C677T and A1298C polymorphisms of the MTHFR gene are genetic ... | BeFree | 17113927 | Detail |
| 0.003 | patent ductus arteriosus | Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C gene polymorphisms ... | BeFree | 24566197 | Detail |
| 0.042 | Diabetic Nephropathy | Synergistic effects of the MTHFR C677T and A1298C polymorphisms on the increased... | BeFree | 20800057 | Detail |
| <0.001 | Ovarian Diseases | Our results showed the significance of MTHFR A1298C and PAI-1 4G/5G mutations in... | BeFree | 22882325 | Detail |
| 0.239 | Coronary heart disease | Methylenetetrahydrofolate reductase gene, homocysteine and coronary artery disea... | BeFree | 18384842 | Detail |
| 0.003 | acute myocardial infarction | We have examined the prevalence of the C677T and A1298C single nucleotide polymo... | BeFree | 17412321 | Detail |
| 0.030 | Malignant neoplasm of prostate | The analysis of the relationship between A1298C and C677T polymorphisms of the M... | BeFree | 19814618 | Detail |
| 0.257 | Cerebrovascular accident | Association of the methylenetetrahydrofolate reductase gene A1298C polymorphism ... | BeFree | 24391036 | Detail |
| 0.219 | schizophrenia | Further evidence that methylenetetrahydrofolate reductase A1298C polymorphism is... | BeFree | 20694488 | Detail |
| 0.029 | Ischemic stroke | Association of the A1298C polymorphism in MTHFR gene with ischemic stroke. | BeFree | 24128767 | Detail |
| 0.146 | Homocysteinemia | A thrombophilic evaluation was performed, revealing hyperhomocysteinemia and met... | BeFree | 24923843 | Detail |
| 0.013 | stomach carcinoma | Recently, methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) mutations... | BeFree | 16886608 | Detail |
| 0.019 | Factor V Leiden mutation | The genetic polymorphisms C677T and A1298C relating to the enzyme methylenetetra... | BeFree | 22924497 | Detail |
| 0.239 | Down syndrome | Evaluation of C677T and A1298C polymorphisms of the MTHFR gene as maternal risk ... | BeFree | 19725133 | Detail |
| 0.146 | Homocysteinemia | Two common polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene... | BeFree | 11274015 | Detail |
| 0.003 | Cleft lip with or without cleft palate | MTHFR 677TT alone and IRF6 820GG together with MTHFR 677CT, but not MTHFR A1298C... | BeFree | 19419265 | Detail |
| 0.257 | Cerebrovascular accident | MTHFR C677T and A1298C polymorphisms and cerebral stroke in two twin gestations. | BeFree | 21113717 | Detail |
| 0.008 | oligospermia | However, the homozygous (C/C) A1298C polymorphism of the MTHFR gene was present ... | BeFree | 22457816 | Detail |
| 0.148 | male infertility | MTHFR A1298C polymorphism and idiopathic male infertility. | BeFree | 20935396 | Detail |
| 0.135 | coronary artery disease | Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms, plasma ... | BeFree | 15135689 | Detail |
| 0.001 | squamous cell carcinoma | We evaluated genetic polymorphisms in the methylenetetrahydrofolate reductase (M... | BeFree | 16950800 | Detail |
| 0.069 | myocardial infarction | Genetic typing found him to be homozygous for a mutation in the methylenetetrahy... | BeFree | 12891167 | Detail |
| <0.001 | varicocele | Is methylenetetrahydrofolate reductase (MTHFR) gene A1298C polymorphism related ... | BeFree | 24456105 | Detail |
| 0.003 | Rectal Carcinoma | The objective of the present study was to evaluate whether germline methylenetet... | BeFree | 17047490 | Detail |
| 0.232 | Precursor Cell Lymphoblastic Leukemia Lymphoma | A meta-analysis of MTHFR C677T and A1298C polymorphisms and risk of acute lympho... | BeFree | 21495160 | Detail |
| 0.337 | hyperhomocysteinemia | The common mutations C677T and A1298C in the human methylenetetrahydrofolate red... | BeFree | 12187094 | Detail |
| 0.148 | male infertility | Relationship between genetic polymorphisms of methylenetetrahydrofolate reductas... | BeFree | 20978181 | Detail |
| 0.219 | schizophrenia | We measured the serum level of homocysteine/folate and methylenetetrahydrofolate... | BeFree | 16641680 | Detail |
| 0.004 | hyperhomocysteinemia | All participants had a thrombotic workup that included the following: genetic ma... | BeFree | 23337711 | Detail |
| 0.016 | Malignant neoplasm of urinary bladder | However, patients heterozygous for MTHFR A1298C or MTR A2756 G genotypes have 1.... | BeFree | 19837268 | Detail |
| <0.001 | Hemophilia, NOS | No decrease in factor consumption was noted in patients with hemophilia having M... | BeFree | 22411997 | Detail |
| 0.005 | major depressive disorder | This study shows that CC genotype of the MTHFR A1298C is associated with higher ... | BeFree | 23255668 | Detail |
| 0.011 | Transient ischemic attack | Cerebral venous sinus thrombosis presenting as transient ischemic attacks in a c... | BeFree | 20833086 | Detail |
| <0.001 | gastric adenocarcinoma | Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and susceptib... | BeFree | 17972183 | Detail |
| 0.036 | Malignant neoplasm of stomach | Recently, methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) mutations... | BeFree | 16886608 | Detail |
| 0.245 | Cardiovascular Diseases | Thus, A1298C polymorphism of MTHFR gene appears to be associated with the severi... | BeFree | 17899317 | Detail |
| 0.101 | Malignant neoplasm of breast | The MTHFR A1298C genotype was associated with a decreased risk of BC [OR=0.68; 9... | BeFree | 24023349 | Detail |
| 0.009 | azoospermia | In conclusion, this meta-analysis supports that the MTHFR A1298C polymorphism is... | BeFree | 22175540 | Detail |
| 0.219 | schizophrenia | The authors performed a meta-analysis of studies examining the association betwe... | BeFree | 17074966 | Detail |
| 0.001 | Chronic Kidney Diseases | We used PCR-RFLP analysis to detect the eNOS G894T, MTHFR C677T and A1298C varia... | BeFree | 19376104 | Detail |
| 0.337 | hyperhomocysteinemia | Hyperhomocysteinemia causes steatosis, and the methylenetetrahydrofolate reducta... | BeFree | 17563923 | Detail |
| 0.047 | leukemia | Our investigation provides interesting data concerning the opposite effect of A1... | BeFree | 16182363 | Detail |
| 0.235 | osteoporosis | The examined SNPs (MTHFR (C677T, and A1298C), TGFβ1 (T869C), and TNFB (A252G)) w... | BeFree | 25981594 | Detail |
| 0.126 | Malnutrition | Elevated levels of plasma homocysteine, an independent risk factor and a strong ... | BeFree | 18384842 | Detail |
| <0.001 | Steatohepatitis | The aim of this study was to investigate the relation between liver steatosis wi... | BeFree | 23547829 | Detail |
| 0.121 | Peripheral neuropathy | We found bilateral peripheral neuropathy, persistent aPL and elevated Lp(a) leve... | BeFree | 23910811 | Detail |
| 0.023 | epilepsy | Screening for C677T and A1298C MTHFR polymorphisms in patients with epilepsy and... | BeFree | 15970629 | Detail |
| 0.006 | Malignant tumor of cervix | The marginal association between the MTHFR A1298C polymorphisms and the suscepti... | BeFree | 23285018 | Detail |
| <0.001 | anemia | Subjects with MTHFR polymorphism for A1298C (AC, CC) had significantly higher MT... | BeFree | 19391036 | Detail |
| 0.021 | Myeloid Leukemia, Chronic | MTHFR A1298C and C677T gene polymorphisms and susceptibility to chronic myeloid ... | BeFree | 24966971 | Detail |
| <0.001 | Experimental Organism Basal Cell Carcinoma | We evaluated genetic polymorphisms in the methylenetetrahydrofolate reductase (M... | BeFree | 16950800 | Detail |
| 0.146 | Homocysteinemia | Compound heterozygosity for the C677T and A1298C mutations of the MTHFR gene in ... | BeFree | 19366086 | Detail |
| 0.008 | Malignant tumor of colon | Using data from an incident case-control study (1608 cases and 1972 controls) we... | BeFree | 14973104 | Detail |
| 0.007 | Carcinoma of lung | Our meta-analysis supports that the common polymorphisms of C677T and A1298C in ... | BeFree | 22215214 | Detail |
| 0.019 | Deep Vein Thrombosis | Patients with homozygous or combined heterozygous status of MTHFR C677T and A129... | BeFree | 18800213 | Detail |
| 0.232 | Precursor Cell Lymphoblastic Leukemia Lymphoma | We conducted a case-control study in 95 north Indian children with acute lymphob... | BeFree | 20367562 | Detail |
| 0.030 | Malignant neoplasm of prostate | Relationship between methylenetetrahydrofolate reductase C677T and A1298C genoty... | BeFree | 15298954 | Detail |
| 0.094 | Diabetes Mellitus, Non-Insulin-Dependent | Synergistic effects of the MTHFR C677T and A1298C polymorphisms on the increased... | BeFree | 20800057 | Detail |
| 0.033 | retinal vein occlusion | Association of methylenetetrahydrofolate reductase (A1298C and C677T) polymorphi... | BeFree | 24440586 | Detail |
| 0.002 | Chronic kidney disease stage 5 | MTHFR A1298C polymorphism is associated with cardiovascular risk in end stage re... | BeFree | 17899317 | Detail |
| 0.036 | Malignant neoplasm of stomach | The polymorphism of methylenetetrahydrofolate reductase C677T but not A1298C con... | BeFree | 23897558 | Detail |
| <0.001 | membranous glomerulonephritis | Cerebral sinovenous thrombosis associated with factor V Leiden and methylenetetr... | BeFree | 21500982 | Detail |
| 0.094 | Diabetes Mellitus, Non-Insulin-Dependent | We investigated the association of C677T and A1298C MTHFR gene variants and alte... | BeFree | 20524928 | Detail |
| 0.016 | Behcet Syndrome | Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and variation... | BeFree | 23827456 | Detail |
| 0.029 | Ischemic stroke | An analysis of the results obtained in this study and a critical review of previ... | BeFree | 25440348 | Detail |
| 0.016 | Acute lymphocytic leukemia | The effect of RFC G80A polymorphism in Cretan children with acute lymphoblastic ... | BeFree | 24237708 | Detail |
| 0.063 | Kidney Failure, Chronic | We used PCR-RFLP analysis to detect the eNOS G894T, MTHFR C677T and A1298C varia... | BeFree | 19376104 | Detail |
| 0.023 | epilepsy | The role of C677T and A1298C polymorphisms of methylenetetrahydrofolate reductas... | BeFree | 24183735 | Detail |
| 0.046 | Coronary Arteriosclerosis | A1298C methylenetetrahydrofolate reductase mutation and coronary artery disease:... | BeFree | 12049191 | Detail |
| 0.135 | coronary artery disease | Methylenetetrahydrofolate reductase gene, homocysteine and coronary artery disea... | BeFree | 18384842 | Detail |
| 0.042 | Malignant neoplasm of esophagus | Genetic polymorphism of MTHFR A1298C and esophageal cancer susceptibility: a met... | BeFree | 23679298 | Detail |
| 0.003 | thrombophilia | The case with factor VIII of 160% had two other thrombophilias (compound MTHFR C... | BeFree | 16015408 | Detail |
| 0.257 | Cerebrovascular accident | Methylenetetrahydrofolate reductase gene A1298C polymorphism in pediatric stroke... | BeFree | 25440348 | Detail |
| 0.168 | congenital heart defects | Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C gene polymorphisms ... | BeFree | 24566197 | Detail |
| 0.003 | Deep Vein Thrombosis | We therefore compared the prevalence of factor V Leiden, prothrombin G20210A, me... | BeFree | 18800213 | Detail |
| 0.026 | colorectal carcinoma | Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and fluoroura... | BeFree | 26111049 | Detail |
| 0.063 | Kidney Failure, Chronic | MTHFR A1298C polymorphism is associated with cardiovascular risk in end stage re... | BeFree | 17899317 | Detail |
| 0.107 | colorectal cancer | Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and fluoroura... | BeFree | 26111049 | Detail |
| 0.016 | Acute lymphocytic leukemia | Certain common polymorphisms within the MTHFR gene (C677T, A1298C) result in red... | BeFree | 18804702 | Detail |
| 0.001 | Myeloid Leukemia, Chronic | We conducted a case-control study analyzing the prevalence of the polymorphisms ... | BeFree | 22576927 | Detail |
| 0.026 | colorectal carcinoma | Association of polymorphisms MTHFR C677T and A1298C with risk of colorectal canc... | BeFree | 19669769 | Detail |
| 0.026 | colorectal carcinoma | We aimed to test the hypothesis that C677T and A1298C variants of MTHFR predispo... | BeFree | 20193847 | Detail |
| <0.001 | Chronic Kidney Insufficiency | We used PCR-RFLP analysis to detect the eNOS G894T, MTHFR C677T and A1298C varia... | BeFree | 19376104 | Detail |
| 0.003 | adult acute lymphocytic leukemia | These results do not support the suggestion that populations carrying different ... | BeFree | 15003888 | Detail |
| 0.216 | thrombophilia | The aim of this study was to verify whether FV Leiden, PT G20210A, MTHFR C667T o... | BeFree | 23157044 | Detail |
| 0.054 | Migraine Disorders | Association of the C677T and A1298C polymorphisms in the 5,10 methylenetetrahydr... | BeFree | 12654508 | Detail |
| 0.015 | Ischemic Cerebrovascular Accident | An analysis of the results obtained in this study and a critical review of previ... | BeFree | 25440348 | Detail |
| 0.204 | rheumatoid arthritis | Methylenetetrahydrofolate reductase polymorphisms, C677T and A1298C, are associa... | BeFree | 21773884 | Detail |
| 0.003 | adult acute lymphocytic leukemia | We previously reported that 2 polymorphisms in the 5,10-methylenetetrahydrofolat... | BeFree | 11986237 | Detail |
| 0.146 | Homocysteinemia | Because they have been described as strong risk factors for idiopathic recurrent... | BeFree | 16452733 | Detail |
| 0.054 | Migraine Disorders | We found a trend toward an increased risk of migraine in subjects carrying a hom... | BeFree | 16686913 | Detail |
| 0.232 | Precursor Cell Lymphoblastic Leukemia Lymphoma | Most studies found a strong association between the polymorphisms MTHFR, C677T o... | BeFree | 17023046 | Detail |
| 0.004 | Activated Protein C Resistance | We detected methylenetetrahydrofolate reductase (MTHFR) A1298C, MTHFR C677T, fac... | BeFree | 20868443 | Detail |
| 0.006 | Mental Retardation | Screening for methylenetetrahydrofolate reductase C677T and A1298C polymorphisms... | BeFree | 18510799 | Detail |
| 0.337 | hyperhomocysteinemia | We investigated whether the MTHFR C677T and A1298C polymorphisms contribute to h... | BeFree | 16629766 | Detail |
| 0.030 | liver carcinoma | Meta-analysis of MTHFR C677T and A1298C gene polymorphisms: association with the... | BeFree | 24316043 | Detail |
| 0.257 | Cerebrovascular accident | A meta-analysis of the relationship between MTHFR gene A1298C polymorphism and t... | BeFree | 25472665 | Detail |
| 0.001 | Adenocarcinoma Of Esophagus | In addition, we found that the MTHFR A1298C polymorphism might influence risk of... | BeFree | 23679298 | Detail |
| 0.011 | multiple sclerosis | Association of methylenetetrahydrofolate reductase A1298C polymorphism but not o... | BeFree | 23523621 | Detail |
| 0.010 | Blood Coagulation Disorders | All 11 cases had one or more familial thrombophilic coagulation disorder includi... | BeFree | 16015408 | Detail |
| 0.011 | Blood Coagulation Disorders | All 11 cases had one or more familial thrombophilic coagulation disorder includi... | BeFree | 16015408 | Detail |
| 0.232 | Precursor Cell Lymphoblastic Leukemia Lymphoma | Methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms and ther... | BeFree | 19391036 | Detail |
| 0.003 | Conventional (Clear Cell) Renal Cell Carcinoma | Methylenetetrahydrofolate reductase (MTHFR) gene C677T, A1298C and G1793A polymo... | BeFree | 21489764 | Detail |
| <0.001 | Experimental Organism Basal Cell Carcinoma | We evaluated genetic polymorphisms in the methylenetetrahydrofolate reductase (M... | BeFree | 16950800 | Detail |
| 0.239 | Coronary heart disease | A1298C methylenetetrahydrofolate reductase mutation and coronary artery disease:... | BeFree | 12049191 | Detail |
| 0.004 | Homocysteinemia | All participants had a thrombotic workup that included the following: genetic ma... | BeFree | 23337711 | Detail |
| 0.036 | Malignant neoplasm of stomach | Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric c... | BeFree | 20470942 | Detail |
| 0.004 | Factor V Leiden mutation | In a total of 543 Turkish women with RPL and 327 of their male partners (870 ind... | BeFree | 22047507 | Detail |
| 0.004 | Adenoma of large intestine | Different roles of MTHFR C677T and A1298C polymorphisms in colorectal adenoma an... | BeFree | 17089070 | Detail |
| 0.168 | congenital heart defects | MTHFR C677T and A1298C polymorphisms as a risk factor for congenital heart defec... | BeFree | 21159028 | Detail |
| 0.115 | Hypertensive disease | We conclude that the MTHFR-coding polymorphism at A1298C is associated with rena... | BeFree | 21613384 | Detail |
| 0.107 | colorectal cancer | C677T and A1298C mutations in the MTHFR gene and survival in colorectal cancer. | BeFree | 20076818 | Detail |
| 0.031 | Leukemia, Lymphocytic, Acute, L1 | The MTHFR C677T and A1298C polymorphisms and susceptibility to childhood acute l... | BeFree | 16096524 | Detail |
| 0.216 | thrombophilia | Severe arterial thrombophilia associated with a homozygous MTHFR gene mutation (... | BeFree | 18160591 | Detail |
| 0.257 | Cerebrovascular accident | Methylenetetrahydrofolate reductase gene polymorphisms are associated with ische... | BeFree | 17113927 | Detail |
| 0.101 | Malignant neoplasm of breast | Interactions between MTHFR C677T-A1298C variants and folic acid deficiency affec... | BeFree | 22901194 | Detail |
| 0.021 | breast carcinoma | Lack of association between methylenetetrahydrofolate reductase gene A1298C poly... | BeFree | 21052845 | Detail |
| 0.337 | hyperhomocysteinemia | MTHFR C677T and A1298C gene polymorphisms and hyperhomocysteinemia as risk facto... | BeFree | 16828193 | Detail |
| 0.135 | coronary artery disease | Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA275... | BeFree | 16268464 | Detail |
| 0.031 | Leukemia, Lymphocytic, Acute, L1 | These results suggest that the MTHFR C677T, but not A1298C, polymorphism is a po... | BeFree | 21495160 | Detail |
| 0.019 | Factor V Leiden mutation | Plasma homocysteine, vitamin B12, folate, creatinine, and protein C levels were ... | BeFree | 20935614 | Detail |
| <0.001 | Lymphoblastic leukemia in children | A meta-analysis of MTHFR C677T and A1298C polymorphisms and risk of acute lympho... | BeFree | 21495160 | Detail |
| 0.004 | Carcinoma of bladder | However, patients heterozygous for MTHFR A1298C or MTR A2756 G genotypes have 1.... | BeFree | 19837268 | Detail |
| <0.001 | Azoospermia, Nonobstructive | The objective of this study was to analyze the distribution of the methylenetetr... | BeFree | 21138341 | Detail |
| 0.017 | Leukemia, Myelocytic, Acute | Association between the MTHFR A1298C polymorphism and increased risk of acute my... | BeFree | 17071478 | Detail |
| 0.155 | Vascular Diseases | Mutations or polymorphisms in the gene of the enzyme methylenetetrahydrofolate r... | BeFree | 17966140 | Detail |
| 0.026 | colorectal carcinoma | Methylenetetrahydrofolate reductase gene germ-line C677T and A1298C SNPs are ass... | BeFree | 25292054 | Detail |
| 0.155 | Vascular Diseases | This study was undertaken to investigate the involvement of MTHFR gene mutations... | BeFree | 11451544 | Detail |
| 0.001 | Non-alcoholic Fatty Liver Disease | MTHFR 677C/T and 1298A/C mutations and non-alcoholic fatty liver disease. | BeFree | 26031974 | Detail |
| 0.002 | Lip and oral cavity carcinoma | Polymorphisms of MTHFR C677T and A1298C association with oral carcinoma risk: a ... | BeFree | 22536935 | Detail |
| <0.001 | THROMBOPHILIA DUE TO ACTIVATED PROTEIN C RESISTANCE (disorder) | We detected methylenetetrahydrofolate reductase (MTHFR) A1298C, MTHFR C677T, fac... | BeFree | 20868443 | Detail |
| 0.135 | coronary artery disease | Homocysteine and methylenetetrahydrofolate reductase C677T and A1298C polymorphi... | BeFree | 18204887 | Detail |
| 0.337 | hyperhomocysteinemia | Two common polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene... | BeFree | 11274015 | Detail |
| 0.146 | Homocysteinemia | Screening for C677T and A1298C MTHFR polymorphisms in patients with epilepsy and... | BeFree | 15970629 | Detail |
| 0.015 | Ischemic Cerebrovascular Accident | Methylenetetrahydrofolate reductase (C677T and A1298C) polymorphisms, hyperhomoc... | BeFree | 23642756 | Detail |
| 0.001 | Experimental Organism Basal Cell Carcinoma | We evaluated genetic polymorphisms in the methylenetetrahydrofolate reductase (M... | BeFree | 16950800 | Detail |
| 0.036 | Malignant neoplasm of stomach | Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric c... | BeFree | 25170232 | Detail |
| 0.337 | hyperhomocysteinemia | The fact that MTHFR A1298C polymorphism is significantly associated with homocys... | BeFree | 16244782 | Detail |
| 0.036 | Malignant neoplasm of stomach | Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A... | BeFree | 18162478 | Detail |
| 0.013 | squamous cell carcinoma | We evaluated genetic polymorphisms in the methylenetetrahydrofolate reductase (M... | BeFree | 16950800 | Detail |
| 0.126 | anemia | Subjects with MTHFR polymorphism for A1298C (AC, CC) had significantly higher MT... | BeFree | 19391036 | Detail |
| 0.004 | hyperhomocysteinemia | All participants had a thrombotic workup that included the following: genetic ma... | BeFree | 23337711 | Detail |
| 0.204 | rheumatoid arthritis | MTHFR gene polymorphisms and outcome of methotrexate treatment in patients with ... | BeFree | 21931346 | Detail |
| 0.016 | Acute lymphocytic leukemia | Most studies found a strong association between the polymorphisms MTHFR, C677T o... | BeFree | 17023046 | Detail |
| 0.010 | Blood Coagulation Disorders | Coagulopathy evaluation revealed C677T/A1298C compound heterozygous genotype for... | BeFree | 17357807 | Detail |
| 0.003 | Diabetes | Methylenetetrahydrofolate reductase A1298C polymorphism and diabetes risk: evide... | BeFree | 24828322 | Detail |
| 0.003 | adult acute lymphocytic leukemia | We evaluated the influence of C677T and A1298C methylenetetrahydrofolate reducta... | BeFree | 17512587 | Detail |
| 0.014 | Carcinogenesis | We concluded that MTHFR A1298C polymorphism may play a protective role in the ca... | BeFree | 23457501 | Detail |
| 0.013 | stomach carcinoma | The polymorphism of methylenetetrahydrofolate reductase C677T but not A1298C con... | BeFree | 23897558 | Detail |
| 0.033 | Esophageal Neoplasms | Genetic polymorphism of MTHFR A1298C and esophageal cancer susceptibility: a met... | BeFree | 23679298 | Detail |
| 0.019 | Deep Vein Thrombosis | The presence of homozygous MTHFR A1298C mutation was significantly associated wi... | BeFree | 21080081 | Detail |
| <0.001 | Lesion of brain | APS, revealed by anti-beta-2-glycoprotein and anti-prothrombin antibodies positi... | BeFree | 16595601 | Detail |
| 0.006 | Turner syndrome | C677T and A1298C polymorphisms of MTHFR gene and their relation to homocysteine ... | BeFree | 22283972 | Detail |
| 0.148 | male infertility | Association of the methylenetetrahydrofolate reductase gene A1298C polymorphism ... | BeFree | 22175540 | Detail |
| 0.031 | Leukemia, Lymphocytic, Acute, L1 | In conclusion, MTHFR C677T was linked to a significant 2.4-fold decreased risk o... | BeFree | 11736945 | Detail |
| <0.001 | membranous glomerulonephritis | Cerebral sinovenous thrombosis associated with factor V Leiden and methylenetetr... | BeFree | 21500982 | Detail |
| 0.219 | schizophrenia | Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and a... | BeFree | 21302350 | Detail |
| 0.020 | diabetes mellitus | Methylenetetrahydrofolate reductase A1298C polymorphism and diabetes risk: evide... | BeFree | 24828322 | Detail |
| 0.131 | autistic disorder | MTHFR A1298C acts additively in increasing the risk for autism. | BeFree | 19440165 | Detail |
| 0.337 | hyperhomocysteinemia | to investigate if NAFLD, in subjects referred for nutritional assessment and cou... | BeFree | 24488901 | Detail |
| 0.146 | Homocysteinemia | The common mutations C677T and A1298C in the human methylenetetrahydrofolate red... | BeFree | 12187094 | Detail |
| 0.004 | Adenoma of large intestine | We assessed 2 polymorphisms in the MTHFR gene (C677T and A1298C) in relation to ... | BeFree | 17087956 | Detail |
| 0.008 | Hemophilia A | No decrease in factor consumption was noted in patients with hemophilia having M... | BeFree | 22411997 | Detail |
| 0.021 | Myeloid Leukemia, Chronic | Methylenetetrahydrofolate reductase A1298C genotypes are associated with the ris... | BeFree | 16706930 | Detail |
| 0.005 | Carotid Atherosclerosis | Thus, A1298C polymorphism of MTHFR gene appears to be associated with the severi... | BeFree | 17899317 | Detail |
| 0.015 | Ischemic Cerebrovascular Accident | Association of the A1298C polymorphism in MTHFR gene with ischemic stroke. | BeFree | 24128767 | Detail |
| 0.004 | prostate carcinoma | Relationship between methylenetetrahydrofolate reductase C677T and A1298C genoty... | BeFree | 15298954 | Detail |
| 0.010 | cervix carcinoma | The marginal association between the MTHFR A1298C polymorphisms and the suscepti... | BeFree | 23285018 | Detail |
| 0.042 | Diabetic Nephropathy | Effects of the C677T and A1298C polymorphisms of the MTHFR gene on the genetic p... | BeFree | 12897091 | Detail |
| 0.337 | hyperhomocysteinemia | Because they have been described as strong risk factors for idiopathic recurrent... | BeFree | 16452733 | Detail |
| 0.001 | childhood leukemia | The maternal methylenetetrahydrofolate reductase A1298C polymorphism was found t... | BeFree | 18339682 | Detail |
| 0.003 | retinoblastoma | A case-control study of 72 retinoblastoma cases and 98 cancer-free children cont... | BeFree | 20310006 | Detail |
| 0.028 | Malignant neoplasm of breast | In this case-control study, we investigated the association between MTHFR C677T ... | BeFree | 22134752 | Detail |
| <0.001 | retinoblastoma | A case-control study of 72 retinoblastoma cases and 98 cancer-free children cont... | BeFree | 20310006 | Detail |
| 0.153 | Down syndrome | In conclusion, the presence of three or more polymorphic alleles for MTHFR C677T... | BeFree | 18273817 | Detail |
| 0.007 | breast carcinoma | In this case-control study, we investigated the association between MTHFR C677T ... | BeFree | 22134752 | Detail |
| 0.135 | Down syndrome | In conclusion, the presence of three or more polymorphic alleles for MTHFR C677T... | BeFree | 18273817 | Detail |
| 0.040 | Down syndrome | The aim of the present study was to investigate the effect of polymorphisms C677... | BeFree | 18273817 | Detail |
| 0.003 | retinoblastoma | A case-control study of 72 retinoblastoma cases and 98 cancer-free children cont... | BeFree | 20310006 | Detail |
| 0.005 | breast carcinoma | In this case-control study, we investigated the association between MTHFR C677T ... | BeFree | 22134752 | Detail |
| 0.035 | Malignant neoplasm of breast | In this case-control study, we investigated the association between MTHFR C677T ... | BeFree | 22134752 | Detail |
| 0.239 | Down syndrome | In conclusion, the presence of three or more polymorphic alleles for MTHFR C677T... | BeFree | 18273817 | Detail |
| 0.002 | Infiltrating Cervical Carcinoma | We performed a case-control association study to evaluate the association betwee... | BeFree | 24474455 | Detail |
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| We performed a case-control association study to evaluate the association between common polymorphis... | DisGeNET | Detail |
| We evaluated the relationship between polymorphisms of methylene-tetrahydrofolate reductase (MTHFR C... | DisGeNET | Detail |
| We evaluated the relationship between polymorphisms of methylene-tetrahydrofolate reductase (MTHFR C... | DisGeNET | Detail |
| We evaluated the relationship between polymorphisms of methylene-tetrahydrofolate reductase (MTHFR C... | DisGeNET | Detail |
| We evaluated the relationship between polymorphisms of methylene-tetrahydrofolate reductase (MTHFR C... | DisGeNET | Detail |
| DNA from leukocytes was tested for: factor V Leiden (mutation G1691A), factor V R2 (H1299R), factor ... | DisGeNET | Detail |
| DNA from leukocytes was tested for: factor V Leiden (mutation G1691A), factor V R2 (H1299R), factor ... | DisGeNET | Detail |
| In this study, the six polymorphisms associated with rheumatoid arthritis (RA), N-acetyltransferase2... | DisGeNET | Detail |
| In this study, the six polymorphisms associated with rheumatoid arthritis (RA), N-acetyltransferase2... | DisGeNET | Detail |
| In this study, the six polymorphisms associated with rheumatoid arthritis (RA), N-acetyltransferase2... | DisGeNET | Detail |
| Viable cell growth, MDI, and polymorphism frequency in MTRR (A66G and C524T) and MTHFR (A1298C and A... | DisGeNET | Detail |
| Viable cell growth, MDI, and polymorphism frequency in MTRR (A66G and C524T) and MTHFR (A1298C and A... | DisGeNET | Detail |
| In this case-control study, we examined C677T and A1298C (rs1801133 and rs1801131) polymorphism in t... | DisGeNET | Detail |
| Two polymorphisms of the MTHFR gene, C677T (rs1801133) and A1298C (rs1801131), were analyzed in a sa... | DisGeNET | Detail |
| Recently, suggestive association has been reported between a single nucleotide polymorphism (SNP; rs... | DisGeNET | Detail |
| We analyzed 821 subjects with hypertensive nephrosclerosis from the longitudinal National Institute ... | DisGeNET | Detail |
| Genetic polymorphisms in MTHFR (C677T, A1298C), MTR (A2756G) and MTRR (A66G) genes associated with p... | DisGeNET | Detail |
| Association between MTHFR C677T and A1298C, and MTRR A66G polymorphisms and susceptibility to schizo... | DisGeNET | Detail |
| We studied several single nucleotide polymorphisms (SNP) in Hcy-regulating genes [methylenetetrahydr... | DisGeNET | Detail |
| This population-based case-control study was designed to investigate the interrelationships between ... | DisGeNET | Detail |
| We found no evidence for an association between any of these variants (MTHFR C677T and A1298C, MTR A... | DisGeNET | Detail |
| Therefore, we carried out a meta-analysis of 26, 17, 9, 15, 9 and 6 case-control studies on the rela... | DisGeNET | Detail |
| Finally, statistically significant associations between the MTHFR A1298C and MTRR A66G gene polymorp... | DisGeNET | Detail |
| Finally, statistically significant associations between the MTHFR A1298C and MTRR A66G gene polymorp... | DisGeNET | Detail |
| We studied several single nucleotide polymorphisms (SNP) in Hcy-regulating genes [methylenetetrahydr... | DisGeNET | Detail |
| Genetic polymorphisms in MTHFR (C677T, A1298C), MTR (A2756G) and MTRR (A66G) genes associated with p... | DisGeNET | Detail |
| Therefore, we carried out a meta-analysis of 26, 17, 9, 15, 9 and 6 case-control studies on the rela... | DisGeNET | Detail |
| Functional polymorphisms in genes encoding one-carbon metabolism enzymes, such as methylenetetrahydr... | DisGeNET | Detail |
| We found no evidence for an association between any of these variants (MTHFR C677T and A1298C, MTR A... | DisGeNET | Detail |
| Genetic polymorphisms in MTHFR (C677T, A1298C), MTR (A2756G) and MTRR (A66G) genes associated with p... | DisGeNET | Detail |
| This study aimed to detect the genotype distributions and allele frequencies of methylenetetrahydrof... | DisGeNET | Detail |
| We studied several single nucleotide polymorphisms (SNP) in Hcy-regulating genes [methylenetetrahydr... | DisGeNET | Detail |
| We studied several single nucleotide polymorphisms (SNP) in Hcy-regulating genes [methylenetetrahydr... | DisGeNET | Detail |
| We studied several single nucleotide polymorphisms (SNP) in Hcy-regulating genes [methylenetetrahydr... | DisGeNET | Detail |
| Genetic polymorphisms in MTHFR (C677T, A1298C), MTR (A2756G) and MTRR (A66G) genes associated with p... | DisGeNET | Detail |
| We studied several single nucleotide polymorphisms (SNP) in Hcy-regulating genes [methylenetetrahydr... | DisGeNET | Detail |
| This study aimed to detect the genotype distributions and allele frequencies of methylenetetrahydrof... | DisGeNET | Detail |
| This population-based case-control study was designed to investigate the interrelationships between ... | DisGeNET | Detail |
| This meta-analysis suggests that MTR A2756G polymorphism, but not MTRR A66G and MTHFR A1298C, is ass... | DisGeNET | Detail |
| Therefore, we carried out a meta-analysis of 26, 17, 9, 15, 9 and 6 case-control studies on the rela... | DisGeNET | Detail |
| Association between MTHFR C677T and A1298C, and MTRR A66G polymorphisms and susceptibility to schizo... | DisGeNET | Detail |
| This meta-analysis suggests that MTR A2756G polymorphism, but not MTRR A66G and MTHFR A1298C, is ass... | DisGeNET | Detail |
| This population-based case-control study was designed to investigate the interrelationships between ... | DisGeNET | Detail |
| This population-based case-control study was designed to investigate the interrelationships between ... | DisGeNET | Detail |
| Genetic polymorphisms in MTHFR (C677T, A1298C), MTR (A2756G) and MTRR (A66G) genes associated with p... | DisGeNET | Detail |
| This population-based case-control study was designed to investigate the interrelationships between ... | DisGeNET | Detail |
| We studied several single nucleotide polymorphisms (SNP) in Hcy-regulating genes [methylenetetrahydr... | DisGeNET | Detail |
| Genetic polymorphisms in MTHFR (C677T, A1298C), MTR (A2756G) and MTRR (A66G) genes associated with p... | DisGeNET | Detail |
| This population-based case-control study was designed to investigate the interrelationships between ... | DisGeNET | Detail |
| A total of 138 children diagnosed as autistic based on Diagnostic and Statistical Manual of Mental D... | DisGeNET | Detail |
| We found no evidence for an association between any of these variants (MTHFR C677T and A1298C, MTR A... | DisGeNET | Detail |
| In a case-control study, we evaluated whether four common polymorphisms in methylenetetrahydrofolate... | DisGeNET | Detail |
| Therefore, we carried out a meta-analysis of 26, 17, 9, 15, 9 and 6 case-control studies on the rela... | DisGeNET | Detail |
| This population-based case-control study was designed to investigate the interrelationships between ... | DisGeNET | Detail |
| We studied several single nucleotide polymorphisms (SNP) in Hcy-regulating genes [methylenetetrahydr... | DisGeNET | Detail |
| Therefore, we carried out a meta-analysis of 26, 17, 9, 15, 9 and 6 case-control studies on the rela... | DisGeNET | Detail |
| We studied several single nucleotide polymorphisms (SNP) in Hcy-regulating genes [methylenetetrahydr... | DisGeNET | Detail |
| This population-based case-control study was designed to investigate the interrelationships between ... | DisGeNET | Detail |
| This meta-analysis suggests that MTR A2756G polymorphism, but not MTRR A66G and MTHFR A1298C, is ass... | DisGeNET | Detail |
| Based on the hypothesis that variants of the cSHMT C1420T together with methionine synthase (MS A275... | DisGeNET | Detail |
| However, limited association is suggested between MTHFR A1298C and MS A2756G polymorphisms with cerv... | DisGeNET | Detail |
| No effects of MTHFR C677T polymorphism on CIN II/III risk and MTHFR A1298C or MS A2756G polymorphism... | DisGeNET | Detail |
| Based on the hypothesis that variants of the cSHMT C1420T together with methionine synthase (MS A275... | DisGeNET | Detail |
| Interaction of MTHFR C677T and A1298C, and MTR A2756G gene polymorphisms in breast cancer risk in a ... | DisGeNET | Detail |
| However, limited association is suggested between MTHFR A1298C and MS A2756G polymorphisms with cerv... | DisGeNET | Detail |
| Methionine synthase A2756G and methylenetetrahydrofolate reductase A1298C polymorphisms are not risk... | DisGeNET | Detail |
| In Xinjiang Uygur subjects, the A1298C polymorphisms in MTHFR and the A2756G polymorphisms in the MS... | DisGeNET | Detail |
| No significant association was found between MTHFR A1298C and MTR A2756G polymorphisms and the risk ... | DisGeNET | Detail |
| Interaction of MTHFR C677T and A1298C, and MTR A2756G gene polymorphisms in breast cancer risk in a ... | DisGeNET | Detail |
| Based on the hypothesis that variants of the cSHMT C1420T together with methionine synthase (MS A275... | DisGeNET | Detail |
| Methionine synthase A2756G and methylenetetrahydrofolate reductase A1298C polymorphisms are not risk... | DisGeNET | Detail |
| No effects of MTHFR C677T polymorphism on CIN II/III risk and MTHFR A1298C or MS A2756G polymorphism... | DisGeNET | Detail |
| Interaction of MTHFR C677T and A1298C, and MTR A2756G gene polymorphisms in breast cancer risk in a ... | DisGeNET | Detail |
| Interaction of MTHFR C677T and A1298C, and MTR A2756G gene polymorphisms in breast cancer risk in a ... | DisGeNET | Detail |
| No significant association was found between MTHFR A1298C and MTR A2756G polymorphisms and the risk ... | DisGeNET | Detail |
| In the group of CA of the cardiovascular system, we observed an association of MTHFR A1298C with dec... | DisGeNET | Detail |
| No effects of MTHFR C677T polymorphism on CIN II/III risk and MTHFR A1298C or MS A2756G polymorphism... | DisGeNET | Detail |
| We have previously reported associations between lymphoma risk and germline polymorphisms in genes o... | DisGeNET | Detail |
| Based on the hypothesis that variants of the cSHMT C1420T together with methionine synthase (MS A275... | DisGeNET | Detail |
| The aim of the present meta-analysis was to determine the effects of two MTHFR (C677T and A1298C) an... | DisGeNET | Detail |
| We used the CVD-StripAssay which is based on the reverse-hybridization principle to identify a total... | DisGeNET | Detail |
| We tested 140 with MI individuals for factor V (FV) Leiden, FV H1299R, Prothrombin G20210A, factor X... | DisGeNET | Detail |
| We tested 140 with MI individuals for factor V (FV) Leiden, FV H1299R, Prothrombin G20210A, factor X... | DisGeNET | Detail |
| We used the CVD-StripAssay which is based on the reverse-hybridization principle to identify a total... | DisGeNET | Detail |
| Analysis of the association of studied MTHFR C677T, A1298C and ACE I/D polymorphisms with albuminuri... | DisGeNET | Detail |
| Our study for the first time demonstrated a synergistic effect between ACE I/D with either MTHFR C67... | DisGeNET | Detail |
| MTHFR C677T, A1298C and ACE I/D polymorphisms as risk factors for diabetic nephropathy among type 2 ... | DisGeNET | Detail |
| Analysis of the association of studied MTHFR C677T, A1298C and ACE I/D polymorphisms with albuminuri... | DisGeNET | Detail |
| We used the CVD-StripAssay which is based on the reverse-hybridization principle to identify a total... | DisGeNET | Detail |
| We used the CVD-StripAssay which is based on the reverse-hybridization principle to identify a total... | DisGeNET | Detail |
| We used the CVD-StripAssay which is based on the reverse-hybridization principle to identify a total... | DisGeNET | Detail |
| MTHFR C677T, A1298C and ACE I/D polymorphisms as risk factors for diabetic nephropathy among type 2 ... | DisGeNET | Detail |
| We used the CVD-StripAssay which is based on the reverse-hybridization principle to identify a total... | DisGeNET | Detail |
| We tested 140 with MI individuals for factor V (FV) Leiden, FV H1299R, Prothrombin G20210A, factor X... | DisGeNET | Detail |
| We used the CVD-StripAssay which is based on the reverse-hybridization principle to identify a total... | DisGeNET | Detail |
| We used the CVD-StripAssay which is based on the reverse-hybridization principle to identify a total... | DisGeNET | Detail |
| We used the CVD-StripAssay which is based on the reverse-hybridization principle to identify a total... | DisGeNET | Detail |
| We used the CVD-StripAssay which is based on the reverse-hybridization principle to identify a total... | DisGeNET | Detail |
| Our study for the first time demonstrated a synergistic effect between ACE I/D with either MTHFR C67... | DisGeNET | Detail |
| We tested 140 with MI individuals for factor V (FV) Leiden, FV H1299R, Prothrombin G20210A, factor X... | DisGeNET | Detail |
| There was a statistical difference between the proportions of the mutated allele frequencies of Beta... | DisGeNET | Detail |
| C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase gene: effect on methotrexa... | DisGeNET | Detail |
| Influence of methylenetetrahydrofolate reductase gene polymorphisms C677T and A1298C on age-associat... | DisGeNET | Detail |
| We evaluated genetic polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene (C677T an... | DisGeNET | Detail |
| Folate metabolism gene polymorphisms MTHFR C677T and A1298C and risk for Down syndrome offspring: a ... | DisGeNET | Detail |
| MTHFR C677T and A1298C gene polymorphisms and hyperhomocysteinemia as risk factors of diabetic nephr... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and the risk of primary h... | DisGeNET | Detail |
| The genetic polymorphisms C677T and A1298C relating to the enzyme methylenetetrahydrofolate reductas... | DisGeNET | Detail |
| The objectives of this study were: to determine plasma total homocysteine tHcy levels and the preval... | DisGeNET | Detail |
| The MTHFR A1298C genotype was associated with a decreased risk of BC [OR=0.68; 95% CI: 0.49-0.95]. | DisGeNET | Detail |
| All participants had a thrombotic workup that included the following: genetic markers: factor V Leid... | DisGeNET | Detail |
| Our results suggest that deficient MTHFR enzyme activity in pregnant women, related to the A1298C va... | DisGeNET | Detail |
| MTHFR C677T and A1298C gene polymorphisms and hyperhomocysteinemia as risk factors of diabetic nephr... | DisGeNET | Detail |
| The fact that MTHFR A1298C polymorphism is significantly associated with homocysteine levels, and th... | DisGeNET | Detail |
| MTHFR A1298C polymorphism was found to be associated with decreased risk of skin toxicity (CC/AC vs.... | DisGeNET | Detail |
| The authors used polymerase chain reaction (PCR) measures for thrombophilia (FVL, PTG, C677T-A1298C ... | DisGeNET | Detail |
| Genetic polymorphism of MTHFR A1298C and esophageal cancer susceptibility: a meta-analysis. | DisGeNET | Detail |
| The authors used polymerase chain reaction (PCR) measures for thrombophilia (FVL, PTG, C677T-A1298C ... | DisGeNET | Detail |
| A1298C methylenetetrahydrofolate reductase mutation and coronary artery disease: relationships with ... | DisGeNET | Detail |
| MTHFR C677T and A1298C polymorphisms were associated with bladder cancer risk and disease progressio... | DisGeNET | Detail |
| We evaluated genetic polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene (C677T an... | DisGeNET | Detail |
| Methotrexate related adverse effects in patients with rheumatoid arthritis are associated with the A... | DisGeNET | Detail |
| A thrombophilic evaluation was performed, revealing hyperhomocysteinemia and methylenetetrahydrofola... | DisGeNET | Detail |
| Association of methylenetetrahydrofolate reductase C677T-A1298C polymorphisms with risk for esophage... | DisGeNET | Detail |
| Interactions between MTHFR C677T-A1298C variants and folic acid deficiency affect breast cancer risk... | DisGeNET | Detail |
| To investigate the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C genotypes and plasma... | DisGeNET | Detail |
| We detected methylenetetrahydrofolate reductase (MTHFR) A1298C, MTHFR C677T, factor V Leiden, PAI-1,... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms and therapy-related toxicity... | DisGeNET | Detail |
| We evaluated genetic polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene (C677T an... | DisGeNET | Detail |
| Effect of the MTHFR C677T and A1298C polymorphisms on survival in patients with advanced CKD and ESR... | DisGeNET | Detail |
| The objectives of this study were: to determine plasma total homocysteine tHcy levels and the preval... | DisGeNET | Detail |
| C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase gene: incidence and effect... | DisGeNET | Detail |
| All 11 cases had one or more familial thrombophilic coagulation disorder including one heterozygous ... | DisGeNET | Detail |
| Associations between the C677T and A1298C polymorphisms of MTHFR and the efficacy and toxicity of me... | DisGeNET | Detail |
| A meta-analysis of MTHFR C677T and A1298C polymorphisms and risk of acute lymphoblastic leukemia in ... | DisGeNET | Detail |
| The analysis of the relationship between A1298C and C677T polymorphisms of the MTHFR gene with prost... | DisGeNET | Detail |
| Meta-analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and risk of ... | DisGeNET | Detail |
| Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) with ... | DisGeNET | Detail |
| Association of polymorphisms MTHFR C677T and A1298C with risk of colorectal cancer, genetic and epig... | DisGeNET | Detail |
| We investigated the influence of elevated homocysteine plasma levels and 2 polymorphisms, 677C/T and... | DisGeNET | Detail |
| This study aimed to investigate the influence of the C677T and A1298C polymorphisms of the MTHFR gen... | DisGeNET | Detail |
| Lack of association between methylenetetrahydrofolate reductase gene A1298C polymorphism and breast ... | DisGeNET | Detail |
| Association between methylenetetrahydrofolate reductase (MTHFR) C677T/A1298C polymorphisms and essen... | DisGeNET | Detail |
| MTHFR (C677T and A1298C) polymorphisms and risk of sporadic distal colorectal adenoma in the UK Flex... | DisGeNET | Detail |
| MTHFR 677TT alone and IRF6 820GG together with MTHFR 677CT, but not MTHFR A1298C, are risks for nons... | DisGeNET | Detail |
| The authors performed a meta-analysis of studies examining the association between polymorphisms in ... | DisGeNET | Detail |
| The aim of our study was to investigate the potential influence of the C677T and A1298C genetic vari... | DisGeNET | Detail |
| There was a statistical difference between the proportions of the mutated allele frequencies of Beta... | DisGeNET | Detail |
| In 118 infants with clinical signs of NE following perinatal HI, thrombophilic factors, such as fact... | DisGeNET | Detail |
| Polymorphisms of MTHFR C677T and A1298C association with oral carcinoma risk: a meta-analysis. | DisGeNET | Detail |
| The genetic polymorphisms C677T and A1298C relating to the enzyme methylenetetrahydrofolate reductas... | DisGeNET | Detail |
| The frequency of two MTHFR mutations, a recently described mutation in the human MTHFR gene A1298C a... | DisGeNET | Detail |
| The aim of the present study was to determine the role of the two most common polymorphisms of the 5... | DisGeNET | Detail |
| We evaluated genetic polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene (C677T an... | DisGeNET | Detail |
| This study shows that CC genotype of the MTHFR A1298C is associated with higher risk of MDD in Slova... | DisGeNET | Detail |
| Gene microarray was used to detect MTHFR C677T and A1298C single nucleotide polymorphism loci on 157... | DisGeNET | Detail |
| We evaluated genetic polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene (C677T an... | DisGeNET | Detail |
| C677T and A1298C methylenetetrahydrofolate reductase (MTHFR) polymorphisms have been suggested to af... | DisGeNET | Detail |
| Effect of the MTHFR C677T and A1298C polymorphisms on survival in patients with advanced CKD and ESR... | DisGeNET | Detail |
| Recently, methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) mutations were discovered to ... | DisGeNET | Detail |
| Our results showed the significance of MTHFR A1298C and PAI-1 4G/5G mutations in Iranian women suffe... | DisGeNET | Detail |
| MTHFR A1298C polymorphism reduces the enzymatic activity and mimics as folate deficiency. | DisGeNET | Detail |
| The methylenetetrahydrofolate reductase (MTHFR) gene C677T and A1298C polymorphisms are commonly ass... | DisGeNET | Detail |
| The aim of this study was to investigate the relation between liver steatosis with plasma homocystei... | DisGeNET | Detail |
| Association of MTHFR C677T and A1298C polymorphisms with non-Hodgkin lymphoma susceptibility: eviden... | DisGeNET | Detail |
| We conducted a case-control study analyzing the prevalence of the polymorphisms MTHFR C677T, MTHFR A... | DisGeNET | Detail |
| MTHFR polymorphisms C677T and A1298C are associated with reduced MTHFR enzyme activity and hyperhomo... | DisGeNET | Detail |
| Influence of methylenetetrahydrofolate reductase gene polymorphisms C677T and A1298C on age-associat... | DisGeNET | Detail |
| APS, revealed by anti-beta-2-glycoprotein and anti-prothrombin antibodies positivity, and moderate H... | DisGeNET | Detail |
| We conducted a case-control study in 95 north Indian children with acute lymphoblastic leukemia (ALL... | DisGeNET | Detail |
| This is the first reported case of intracardiac thrombosis with MTHFR A1298C and factor XIII V34L mu... | DisGeNET | Detail |
| Association between MTHFR C677T, MTHFR A1298C and MS A2756G polymorphisms and risk of cervical intra... | DisGeNET | Detail |
| The aim of our study was to examine the association of selected thrombophilic polymorphisms (factor ... | DisGeNET | Detail |
| Association of the MTHFR A1298C variant with unexplained severe male infertility. | DisGeNET | Detail |
| Association of the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene with s... | DisGeNET | Detail |
| The association between two common mutations C677T and A1298C in human methylenetetrahydrofolate red... | DisGeNET | Detail |
| Placenta slides of 65 IUFDs with known maternal thrombophilia test results (compound MTHFR C677T and... | DisGeNET | Detail |
| Hyperhomocysteinemia is considered an independent risk factor for liver diseases, and the genetic po... | DisGeNET | Detail |
| Certain common polymorphisms within the MTHFR gene (C677T, A1298C) result in reduced enzymatic activ... | DisGeNET | Detail |
| Different roles of MTHFR C677T and A1298C polymorphisms in colorectal adenoma and colorectal cancer:... | DisGeNET | Detail |
| We examined the relationship between MTHFR C677T and A1298C gene polymorphisms and risk of distal ad... | DisGeNET | Detail |
| Role of methylenetetrahydrofolate reductase A1298C polymorphism in cerebral venous thrombosis. | DisGeNET | Detail |
| Association between MTHFR C677T, MTHFR A1298C and MS A2756G polymorphisms and risk of cervical intra... | DisGeNET | Detail |
| We found that the homozygous CC allele of MTHFR A1298C conferred an increased risk of embryonal CNS ... | DisGeNET | Detail |
| We aimed to test the hypothesis that C677T and A1298C variants of MTHFR predispose to microsatellite... | DisGeNET | Detail |
| Gene microarray was used to detect MTHFR C677T and A1298C single nucleotide polymorphism loci on 157... | DisGeNET | Detail |
| Homocysteine and methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in Tunisian pati... | DisGeNET | Detail |
| We conclude that the MTHFR-coding polymorphism at A1298C is associated with renal decline in African... | DisGeNET | Detail |
| MTHFR C677T and A1298C polymorphisms and cervical carcinoma susceptibility: meta-analyses based on 4... | DisGeNET | Detail |
| We evaluated genetic polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene (C677T an... | DisGeNET | Detail |
| We investigated the influence of elevated homocysteine plasma levels and 2 polymorphisms, 677C/T and... | DisGeNET | Detail |
| Subjects were screened for the metabolic syndrome (National Cholesterol Education Program Adult Trea... | DisGeNET | Detail |
| We evaluated genetic polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene (C677T an... | DisGeNET | Detail |
| Role of methylenetetrahydrofolate reductase gene polymorphisms (C677T, A1298C, and G1793A) in the de... | DisGeNET | Detail |
| Screening for C677T and A1298C MTHFR polymorphisms in patients with epilepsy and risk of hyperhomocy... | DisGeNET | Detail |
| Effect of the MTHFR C677T and A1298C polymorphisms on survival in patients with advanced CKD and ESR... | DisGeNET | Detail |
| Recently, methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) mutations were discovered to ... | DisGeNET | Detail |
| We detected methylenetetrahydrofolate reductase (MTHFR) A1298C, MTHFR C677T, factor V Leiden, PAI-1,... | DisGeNET | Detail |
| MTHFR polymorphisms C677T and A1298C are associated with reduced MTHFR enzyme activity and hyperhomo... | DisGeNET | Detail |
| to investigate if NAFLD, in subjects referred for nutritional assessment and counselling, has any di... | DisGeNET | Detail |
| Hyperhomocysteinemia causes steatosis, and the methylenetetrahydrofolate reductase (MTHFR) C677T and... | DisGeNET | Detail |
| Because the fetus is lost in a great proportion of trisomy 21 pregnancies, both maternal and fetal, ... | DisGeNET | Detail |
| No significant associations between the groups were found when samples were analyzed for the MTHFR A... | DisGeNET | Detail |
| The proband's 69-year-old father, with NAION and ischemic stroke, had PTG heterozygosity, familial h... | DisGeNET | Detail |
| Certain common polymorphisms within the MTHFR gene (C677T, A1298C) result in reduced enzymatic activ... | DisGeNET | Detail |
| The methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms are associated with c... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms and therapy-related toxicity... | DisGeNET | Detail |
| Pediatric stroke and methylenetetrahydrofolate reductase polymorphisms: an examination of C677T and ... | DisGeNET | Detail |
| The examined SNPs (MTHFR (C677T, and A1298C), TGFβ1 (T869C), and TNFB (A252G)) were tested by genoty... | DisGeNET | Detail |
| These results in the present study suggested that polymorphisms of the MTHFR C677T could influence s... | DisGeNET | Detail |
| Compound heterozygosity for the C677T and A1298C mutations of the MTHFR gene in a case of hyperhomoc... | DisGeNET | Detail |
| The MTHFR polymorphism (C677T and A1298C) resulted in different outcomes regarding homocysteinemia a... | DisGeNET | Detail |
| Relationship between three polymorphisms of methylenetetrahydrofolate reductase (MTHFR C677T, A1298C... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms in patients with small cell ... | DisGeNET | Detail |
| All participants had a thrombotic workup that included the following: genetic markers: factor V Leid... | DisGeNET | Detail |
| Relationship between methylenetetrahydrofolate reductase (MTHFR) A1298C gene polymorphism and type 2... | DisGeNET | Detail |
| The effect of RFC G80A polymorphism in Cretan children with acute lymphoblastic leukemia and its int... | DisGeNET | Detail |
| MTHFR A1298C (heterozygous) was associated with a reduced risk of diplegia developing at 32 to 36 we... | DisGeNET | Detail |
| Lack of association between MTHFR C677T and MTHFR A1298C genetic polymorphisms and mental retardatio... | DisGeNET | Detail |
| Our meta-analysis supports that the common polymorphisms of C677T and A1298C in MTHFR gene are not s... | DisGeNET | Detail |
| Plasma homocysteine, vitamin B12, folate, creatinine, and protein C levels were measured in all stud... | DisGeNET | Detail |
| MTHFR C677T and A1298C polymorphisms as a risk factor for congenital heart defects in Down syndrome. | DisGeNET | Detail |
| The MTHFR C677T and A1298C polymorphisms are not significant risk factors in adult acute leukemia in... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase A1298C genotypes are associated with the risks of acute lymphobl... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and colorectal cancer: the Fukuok... | DisGeNET | Detail |
| All 11 cases had one or more familial thrombophilic coagulation disorder including one heterozygous ... | DisGeNET | Detail |
| MTHFR gene C677T and A1298C polymorphisms and homocysteine levels in primary open angle and primary ... | DisGeNET | Detail |
| The objective of this study was to analyze the distribution of the methylenetetrahydrofolate reducta... | DisGeNET | Detail |
| A1298C polymorphism in the MTHFR gene predisposes to cardiovascular risk in rheumatoid arthritis. | DisGeNET | Detail |
| We identified the carriage of the MTHFR A1298C polymorphism as a significant risk factor for vascula... | DisGeNET | Detail |
| Different roles of MTHFR C677T and A1298C polymorphisms in colorectal adenoma and colorectal cancer:... | DisGeNET | Detail |
| The aim of this study was to investigate the relation between liver steatosis with plasma homocystei... | DisGeNET | Detail |
| Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) with ... | DisGeNET | Detail |
| We investigated 2 polymorphisms in the MTHFR gene (C677T and A1298C) and their associations with col... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer susceptibility... | DisGeNET | Detail |
| The objectives of this study were: to determine plasma total homocysteine tHcy levels and the preval... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase (C677T and A1298C) polymorphisms, hyperhomocysteinemia, and isch... | DisGeNET | Detail |
| We investigated the influence of elevated homocysteine plasma levels and 2 polymorphisms, 677C/T and... | DisGeNET | Detail |
| Most studies found a strong association between the polymorphisms MTHFR, C677T or A1298C, and NQO1*2... | DisGeNET | Detail |
| Meta-analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and risk of ... | DisGeNET | Detail |
| In 118 infants with clinical signs of NE following perinatal HI, thrombophilic factors, such as fact... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase polymorphisms C677T and A1298C as maternal risk factors for Down... | DisGeNET | Detail |
| MTHFR C677T and A1298C polymorphisms were associated with bladder cancer risk and disease progressio... | DisGeNET | Detail |
| MTHFR C677T and A1298C gene polymorphisms and hyperhomocysteinemia as risk factors of diabetic nephr... | DisGeNET | Detail |
| Certain common polymorphisms within the MTHFR gene (C677T, A1298C) result in reduced enzymatic activ... | DisGeNET | Detail |
| Association of the methylenetetrahydrofolate reductase A1298C but not the C677T single nucleotide po... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase gene germ-line C677T and A1298C SNPs are associated with colorec... | DisGeNET | Detail |
| Association of the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene in pat... | DisGeNET | Detail |
| C677T and A1298C mutations in the MTHFR gene and survival in colorectal cancer. | DisGeNET | Detail |
| Evaluation of C677T and A1298C polymorphisms of the MTHFR gene as maternal risk factors for Down syn... | DisGeNET | Detail |
| We detected methylenetetrahydrofolate reductase (MTHFR) A1298C, MTHFR C677T, factor V Leiden, PAI-1,... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms, plasma homocysteine, folate... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase gene, homocysteine and coronary artery disease: the A1298C polym... | DisGeNET | Detail |
| However, patients heterozygous for MTHFR A1298C or MTR A2756 G genotypes have 1.62- and 2.13-fold hi... | DisGeNET | Detail |
| Interactions between MTHFR C677T-A1298C variants and folic acid deficiency affect breast cancer risk... | DisGeNET | Detail |
| Influence of methylenetetrahydrofolate reductase gene polymorphisms C677T and A1298C on age-associat... | DisGeNET | Detail |
| Association of the MTHFR C677T and A1298C polymorphisms with methotrexate toxicity in rheumatoid art... | DisGeNET | Detail |
| In a total of 543 Turkish women with RPL and 327 of their male partners (870 individuals with RPL), ... | DisGeNET | Detail |
| Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms ... | DisGeNET | Detail |
| Association between 5,10-methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and cono... | DisGeNET | Detail |
| Two common MTHFR gene polymorphisms (C677T and A1298C) have been implicated in the etiology of nonsy... | DisGeNET | Detail |
| APS, revealed by anti-beta-2-glycoprotein and anti-prothrombin antibodies positivity, and moderate H... | DisGeNET | Detail |
| Polymorphisms C677T and A1298C in the MTHFR gene in Mexican patients with rheumatoid arthritis treat... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase (MTHFR): incidence of mutations C677T and A1298C in Brazilian po... | DisGeNET | Detail |
| APS, revealed by anti-beta-2-glycoprotein and anti-prothrombin antibodies positivity, and moderate H... | DisGeNET | Detail |
| Most studies found a strong association between the polymorphisms MTHFR, C677T or A1298C, and NQO1*2... | DisGeNET | Detail |
| Hyperhomocysteinemia is considered an independent risk factor for liver diseases, and the genetic po... | DisGeNET | Detail |
| In conclusion, the C677T and A1298C polymorphisms of the MTHFR gene are genetic risk factors for ham... | DisGeNET | Detail |
| We detected methylenetetrahydrofolate reductase (MTHFR) A1298C, MTHFR C677T, factor V Leiden, PAI-1,... | DisGeNET | Detail |
| MTHFR C677T and A1298C gene polymorphisms and their relation to homocysteine level in Egyptian child... | DisGeNET | Detail |
| Homocysteine and methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in Tunisian pati... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and colorectal cancer: the Fukuok... | DisGeNET | Detail |
| The common mutations C677T and A1298C in the human methylenetetrahydrofolate reductase gene are asso... | DisGeNET | Detail |
| Association of the 5,10-methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) polymorphisms i... | DisGeNET | Detail |
| The case with factor VIII of 160% had two other thrombophilias (compound MTHFR C677T-A1298C heterozy... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer: a meta-analys... | DisGeNET | Detail |
| We investigated whether the MTHFR C677T and A1298C polymorphisms contribute to hyperhomocysteinemia ... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms, plasma homocysteine, folate... | DisGeNET | Detail |
| However, patients heterozygous for MTHFR A1298C or MTR A2756 G genotypes have 1.62- and 2.13-fold hi... | DisGeNET | Detail |
| Relationship between three polymorphisms of methylenetetrahydrofolate reductase (MTHFR C677T, A1298C... | DisGeNET | Detail |
| No association between MTHFR A1298C gene polymorphism and head and neck cancer risk: a meta-analysis... | DisGeNET | Detail |
| The aim of the present study was to determine the role of the two most common polymorphisms of the 5... | DisGeNET | Detail |
| All participants had a thrombotic workup that included the following: genetic markers: factor V Leid... | DisGeNET | Detail |
| Using data from an incident case-control study (1608 cases and 1972 controls) we investigated two po... | DisGeNET | Detail |
| In conclusion, the C677T and A1298C polymorphisms of the MTHFR gene are genetic risk factors for ham... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C gene polymorphisms are associated with ... | DisGeNET | Detail |
| Synergistic effects of the MTHFR C677T and A1298C polymorphisms on the increased risk of micro- and ... | DisGeNET | Detail |
| Our results showed the significance of MTHFR A1298C and PAI-1 4G/5G mutations in Iranian women suffe... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase gene, homocysteine and coronary artery disease: the A1298C polym... | DisGeNET | Detail |
| We have examined the prevalence of the C677T and A1298C single nucleotide polymorphisms (SNPs) in th... | DisGeNET | Detail |
| The analysis of the relationship between A1298C and C677T polymorphisms of the MTHFR gene with prost... | DisGeNET | Detail |
| Association of the methylenetetrahydrofolate reductase gene A1298C polymorphism with stroke risk bas... | DisGeNET | Detail |
| Further evidence that methylenetetrahydrofolate reductase A1298C polymorphism is a risk factor for s... | DisGeNET | Detail |
| Association of the A1298C polymorphism in MTHFR gene with ischemic stroke. | DisGeNET | Detail |
| A thrombophilic evaluation was performed, revealing hyperhomocysteinemia and methylenetetrahydrofola... | DisGeNET | Detail |
| Recently, methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) mutations were discovered to ... | DisGeNET | Detail |
| The genetic polymorphisms C677T and A1298C relating to the enzyme methylenetetrahydrofolate reductas... | DisGeNET | Detail |
| Evaluation of C677T and A1298C polymorphisms of the MTHFR gene as maternal risk factors for Down syn... | DisGeNET | Detail |
| Two common polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene, the thermolabile C... | DisGeNET | Detail |
| MTHFR 677TT alone and IRF6 820GG together with MTHFR 677CT, but not MTHFR A1298C, are risks for nons... | DisGeNET | Detail |
| MTHFR C677T and A1298C polymorphisms and cerebral stroke in two twin gestations. | DisGeNET | Detail |
| However, the homozygous (C/C) A1298C polymorphism of the MTHFR gene was present at a statistically h... | DisGeNET | Detail |
| MTHFR A1298C polymorphism and idiopathic male infertility. | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms, plasma homocysteine, folate... | DisGeNET | Detail |
| We evaluated genetic polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene (C677T an... | DisGeNET | Detail |
| Genetic typing found him to be homozygous for a mutation in the methylenetetrahydrofolate reductase ... | DisGeNET | Detail |
| Is methylenetetrahydrofolate reductase (MTHFR) gene A1298C polymorphism related with varicocele risk... | DisGeNET | Detail |
| The objective of the present study was to evaluate whether germline methylenetetrahydrofolate reduct... | DisGeNET | Detail |
| A meta-analysis of MTHFR C677T and A1298C polymorphisms and risk of acute lymphoblastic leukemia in ... | DisGeNET | Detail |
| The common mutations C677T and A1298C in the human methylenetetrahydrofolate reductase gene are asso... | DisGeNET | Detail |
| Relationship between genetic polymorphisms of methylenetetrahydrofolate reductase (C677T, A1298C, an... | DisGeNET | Detail |
| We measured the serum level of homocysteine/folate and methylenetetrahydrofolate reductase C677T/A12... | DisGeNET | Detail |
| All participants had a thrombotic workup that included the following: genetic markers: factor V Leid... | DisGeNET | Detail |
| However, patients heterozygous for MTHFR A1298C or MTR A2756 G genotypes have 1.62- and 2.13-fold hi... | DisGeNET | Detail |
| No decrease in factor consumption was noted in patients with hemophilia having MTHFR A1298C mutation... | DisGeNET | Detail |
| This study shows that CC genotype of the MTHFR A1298C is associated with higher risk of MDD in Slova... | DisGeNET | Detail |
| Cerebral venous sinus thrombosis presenting as transient ischemic attacks in a case with homozygous ... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and susceptibility to gastric ade... | DisGeNET | Detail |
| Recently, methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) mutations were discovered to ... | DisGeNET | Detail |
| Thus, A1298C polymorphism of MTHFR gene appears to be associated with the severity of carotid athero... | DisGeNET | Detail |
| The MTHFR A1298C genotype was associated with a decreased risk of BC [OR=0.68; 95% CI: 0.49-0.95]. | DisGeNET | Detail |
| In conclusion, this meta-analysis supports that the MTHFR A1298C polymorphism is capable of causing ... | DisGeNET | Detail |
| The authors performed a meta-analysis of studies examining the association between polymorphisms in ... | DisGeNET | Detail |
| We used PCR-RFLP analysis to detect the eNOS G894T, MTHFR C677T and A1298C variants in 100 patients ... | DisGeNET | Detail |
| Hyperhomocysteinemia causes steatosis, and the methylenetetrahydrofolate reductase (MTHFR) C677T and... | DisGeNET | Detail |
| Our investigation provides interesting data concerning the opposite effect of A1298C polymorphisms, ... | DisGeNET | Detail |
| The examined SNPs (MTHFR (C677T, and A1298C), TGFβ1 (T869C), and TNFB (A252G)) were tested by genoty... | DisGeNET | Detail |
| Elevated levels of plasma homocysteine, an independent risk factor and a strong predictor of mortali... | DisGeNET | Detail |
| The aim of this study was to investigate the relation between liver steatosis with plasma homocystei... | DisGeNET | Detail |
| We found bilateral peripheral neuropathy, persistent aPL and elevated Lp(a) level and heterozygous A... | DisGeNET | Detail |
| Screening for C677T and A1298C MTHFR polymorphisms in patients with epilepsy and risk of hyperhomocy... | DisGeNET | Detail |
| The marginal association between the MTHFR A1298C polymorphisms and the susceptibility to cervical c... | DisGeNET | Detail |
| Subjects with MTHFR polymorphism for A1298C (AC, CC) had significantly higher MTX levels at 48 h (p ... | DisGeNET | Detail |
| MTHFR A1298C and C677T gene polymorphisms and susceptibility to chronic myeloid leukemia in Egypt. | DisGeNET | Detail |
| We evaluated genetic polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene (C677T an... | DisGeNET | Detail |
| Compound heterozygosity for the C677T and A1298C mutations of the MTHFR gene in a case of hyperhomoc... | DisGeNET | Detail |
| Using data from an incident case-control study (1608 cases and 1972 controls) we investigated two po... | DisGeNET | Detail |
| Our meta-analysis supports that the common polymorphisms of C677T and A1298C in MTHFR gene are not s... | DisGeNET | Detail |
| Patients with homozygous or combined heterozygous status of MTHFR C677T and A1298C mutation had a hi... | DisGeNET | Detail |
| We conducted a case-control study in 95 north Indian children with acute lymphoblastic leukemia (ALL... | DisGeNET | Detail |
| Relationship between methylenetetrahydrofolate reductase C677T and A1298C genotypes and haplotypes a... | DisGeNET | Detail |
| Synergistic effects of the MTHFR C677T and A1298C polymorphisms on the increased risk of micro- and ... | DisGeNET | Detail |
| Association of methylenetetrahydrofolate reductase (A1298C and C677T) polymorphisms with retinal vei... | DisGeNET | Detail |
| MTHFR A1298C polymorphism is associated with cardiovascular risk in end stage renal disease in North... | DisGeNET | Detail |
| The polymorphism of methylenetetrahydrofolate reductase C677T but not A1298C contributes to gastric ... | DisGeNET | Detail |
| Cerebral sinovenous thrombosis associated with factor V Leiden and methylenetetrahydrofolate reducta... | DisGeNET | Detail |
| We investigated the association of C677T and A1298C MTHFR gene variants and altered homocysteine con... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and variations of homocysteine co... | DisGeNET | Detail |
| An analysis of the results obtained in this study and a critical review of previously published stud... | DisGeNET | Detail |
| The effect of RFC G80A polymorphism in Cretan children with acute lymphoblastic leukemia and its int... | DisGeNET | Detail |
| We used PCR-RFLP analysis to detect the eNOS G894T, MTHFR C677T and A1298C variants in 100 patients ... | DisGeNET | Detail |
| The role of C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene (MTHFR) on th... | DisGeNET | Detail |
| A1298C methylenetetrahydrofolate reductase mutation and coronary artery disease: relationships with ... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase gene, homocysteine and coronary artery disease: the A1298C polym... | DisGeNET | Detail |
| Genetic polymorphism of MTHFR A1298C and esophageal cancer susceptibility: a meta-analysis. | DisGeNET | Detail |
| The case with factor VIII of 160% had two other thrombophilias (compound MTHFR C677T-A1298C heterozy... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase gene A1298C polymorphism in pediatric stroke--case-control and f... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C gene polymorphisms are associated with ... | DisGeNET | Detail |
| We therefore compared the prevalence of factor V Leiden, prothrombin G20210A, methylenetetrahydrofol... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and fluorouracil-based treatment ... | DisGeNET | Detail |
| MTHFR A1298C polymorphism is associated with cardiovascular risk in end stage renal disease in North... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and fluorouracil-based treatment ... | DisGeNET | Detail |
| Certain common polymorphisms within the MTHFR gene (C677T, A1298C) result in reduced enzymatic activ... | DisGeNET | Detail |
| We conducted a case-control study analyzing the prevalence of the polymorphisms MTHFR C677T, MTHFR A... | DisGeNET | Detail |
| Association of polymorphisms MTHFR C677T and A1298C with risk of colorectal cancer, genetic and epig... | DisGeNET | Detail |
| We aimed to test the hypothesis that C677T and A1298C variants of MTHFR predispose to microsatellite... | DisGeNET | Detail |
| We used PCR-RFLP analysis to detect the eNOS G894T, MTHFR C677T and A1298C variants in 100 patients ... | DisGeNET | Detail |
| These results do not support the suggestion that populations carrying different genotypes of the two... | DisGeNET | Detail |
| The aim of this study was to verify whether FV Leiden, PT G20210A, MTHFR C667T or MTHFR A1298C mutat... | DisGeNET | Detail |
| Association of the C677T and A1298C polymorphisms in the 5,10 methylenetetrahydrofolate reductase ge... | DisGeNET | Detail |
| An analysis of the results obtained in this study and a critical review of previously published stud... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase polymorphisms, C677T and A1298C, are associated with methotrexat... | DisGeNET | Detail |
| We previously reported that 2 polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) ... | DisGeNET | Detail |
| Because they have been described as strong risk factors for idiopathic recurrent pregnancy losses (R... | DisGeNET | Detail |
| We found a trend toward an increased risk of migraine in subjects carrying a homozygous mutant genot... | DisGeNET | Detail |
| Most studies found a strong association between the polymorphisms MTHFR, C677T or A1298C, and NQO1*2... | DisGeNET | Detail |
| We detected methylenetetrahydrofolate reductase (MTHFR) A1298C, MTHFR C677T, factor V Leiden, PAI-1,... | DisGeNET | Detail |
| Screening for methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in Indian patients ... | DisGeNET | Detail |
| We investigated whether the MTHFR C677T and A1298C polymorphisms contribute to hyperhomocysteinemia ... | DisGeNET | Detail |
| Meta-analysis of MTHFR C677T and A1298C gene polymorphisms: association with the risk of hepatocellu... | DisGeNET | Detail |
| A meta-analysis of the relationship between MTHFR gene A1298C polymorphism and the risk of adult str... | DisGeNET | Detail |
| In addition, we found that the MTHFR A1298C polymorphism might influence risk ofESCC and EAC in the ... | DisGeNET | Detail |
| Association of methylenetetrahydrofolate reductase A1298C polymorphism but not of C677T with multipl... | DisGeNET | Detail |
| All 11 cases had one or more familial thrombophilic coagulation disorder including one heterozygous ... | DisGeNET | Detail |
| All 11 cases had one or more familial thrombophilic coagulation disorder including one heterozygous ... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms and therapy-related toxicity... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase (MTHFR) gene C677T, A1298C and G1793A polymorphisms: association... | DisGeNET | Detail |
| We evaluated genetic polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene (C677T an... | DisGeNET | Detail |
| A1298C methylenetetrahydrofolate reductase mutation and coronary artery disease: relationships with ... | DisGeNET | Detail |
| All participants had a thrombotic workup that included the following: genetic markers: factor V Leid... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer: a meta-analys... | DisGeNET | Detail |
| In a total of 543 Turkish women with RPL and 327 of their male partners (870 individuals with RPL), ... | DisGeNET | Detail |
| Different roles of MTHFR C677T and A1298C polymorphisms in colorectal adenoma and colorectal cancer:... | DisGeNET | Detail |
| MTHFR C677T and A1298C polymorphisms as a risk factor for congenital heart defects in Down syndrome. | DisGeNET | Detail |
| We conclude that the MTHFR-coding polymorphism at A1298C is associated with renal decline in African... | DisGeNET | Detail |
| C677T and A1298C mutations in the MTHFR gene and survival in colorectal cancer. | DisGeNET | Detail |
| The MTHFR C677T and A1298C polymorphisms and susceptibility to childhood acute lymphoblastic leukemi... | DisGeNET | Detail |
| Severe arterial thrombophilia associated with a homozygous MTHFR gene mutation (A1298C) in a young m... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase gene polymorphisms are associated with ischemic and hemorrhagic ... | DisGeNET | Detail |
| Interactions between MTHFR C677T-A1298C variants and folic acid deficiency affect breast cancer risk... | DisGeNET | Detail |
| Lack of association between methylenetetrahydrofolate reductase gene A1298C polymorphism and breast ... | DisGeNET | Detail |
| MTHFR C677T and A1298C gene polymorphisms and hyperhomocysteinemia as risk factors of diabetic nephr... | DisGeNET | Detail |
| Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) with ... | DisGeNET | Detail |
| These results suggest that the MTHFR C677T, but not A1298C, polymorphism is a potential biomarker fo... | DisGeNET | Detail |
| Plasma homocysteine, vitamin B12, folate, creatinine, and protein C levels were measured in all stud... | DisGeNET | Detail |
| A meta-analysis of MTHFR C677T and A1298C polymorphisms and risk of acute lymphoblastic leukemia in ... | DisGeNET | Detail |
| However, patients heterozygous for MTHFR A1298C or MTR A2756 G genotypes have 1.62- and 2.13-fold hi... | DisGeNET | Detail |
| The objective of this study was to analyze the distribution of the methylenetetrahydrofolate reducta... | DisGeNET | Detail |
| Association between the MTHFR A1298C polymorphism and increased risk of acute myeloid leukemia in Br... | DisGeNET | Detail |
| Mutations or polymorphisms in the gene of the enzyme methylenetetrahydrofolate reductase (MTHFR), as... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase gene germ-line C677T and A1298C SNPs are associated with colorec... | DisGeNET | Detail |
| This study was undertaken to investigate the involvement of MTHFR gene mutations C677T and A1298C im... | DisGeNET | Detail |
| MTHFR 677C/T and 1298A/C mutations and non-alcoholic fatty liver disease. | DisGeNET | Detail |
| Polymorphisms of MTHFR C677T and A1298C association with oral carcinoma risk: a meta-analysis. | DisGeNET | Detail |
| We detected methylenetetrahydrofolate reductase (MTHFR) A1298C, MTHFR C677T, factor V Leiden, PAI-1,... | DisGeNET | Detail |
| Homocysteine and methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in Tunisian pati... | DisGeNET | Detail |
| Two common polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene, the thermolabile C... | DisGeNET | Detail |
| Screening for C677T and A1298C MTHFR polymorphisms in patients with epilepsy and risk of hyperhomocy... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase (C677T and A1298C) polymorphisms, hyperhomocysteinemia, and isch... | DisGeNET | Detail |
| We evaluated genetic polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene (C677T an... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer susceptibility... | DisGeNET | Detail |
| The fact that MTHFR A1298C polymorphism is significantly associated with homocysteine levels, and th... | DisGeNET | Detail |
| Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms ... | DisGeNET | Detail |
| We evaluated genetic polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene (C677T an... | DisGeNET | Detail |
| Subjects with MTHFR polymorphism for A1298C (AC, CC) had significantly higher MTX levels at 48 h (p ... | DisGeNET | Detail |
| All participants had a thrombotic workup that included the following: genetic markers: factor V Leid... | DisGeNET | Detail |
| MTHFR gene polymorphisms and outcome of methotrexate treatment in patients with rheumatoid arthritis... | DisGeNET | Detail |
| Most studies found a strong association between the polymorphisms MTHFR, C677T or A1298C, and NQO1*2... | DisGeNET | Detail |
| Coagulopathy evaluation revealed C677T/A1298C compound heterozygous genotype for MTHFR, and plasma h... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase A1298C polymorphism and diabetes risk: evidence from a meta-anal... | DisGeNET | Detail |
| We evaluated the influence of C677T and A1298C methylenetetrahydrofolate reductase (MTHFR) polymorph... | DisGeNET | Detail |
| We concluded that MTHFR A1298C polymorphism may play a protective role in the carcinogenesis of HCC. | DisGeNET | Detail |
| The polymorphism of methylenetetrahydrofolate reductase C677T but not A1298C contributes to gastric ... | DisGeNET | Detail |
| Genetic polymorphism of MTHFR A1298C and esophageal cancer susceptibility: a meta-analysis. | DisGeNET | Detail |
| The presence of homozygous MTHFR A1298C mutation was significantly associated with DVT (P=0.020). | DisGeNET | Detail |
| APS, revealed by anti-beta-2-glycoprotein and anti-prothrombin antibodies positivity, and moderate H... | DisGeNET | Detail |
| C677T and A1298C polymorphisms of MTHFR gene and their relation to homocysteine levels in Turner syn... | DisGeNET | Detail |
| Association of the methylenetetrahydrofolate reductase gene A1298C polymorphism with male infertilit... | DisGeNET | Detail |
| In conclusion, MTHFR C677T was linked to a significant 2.4-fold decreased risk of developing childho... | DisGeNET | Detail |
| Cerebral sinovenous thrombosis associated with factor V Leiden and methylenetetrahydrofolate reducta... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and age of onset in schiz... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase A1298C polymorphism and diabetes risk: evidence from a meta-anal... | DisGeNET | Detail |
| MTHFR A1298C acts additively in increasing the risk for autism. | DisGeNET | Detail |
| to investigate if NAFLD, in subjects referred for nutritional assessment and counselling, has any di... | DisGeNET | Detail |
| The common mutations C677T and A1298C in the human methylenetetrahydrofolate reductase gene are asso... | DisGeNET | Detail |
| We assessed 2 polymorphisms in the MTHFR gene (C677T and A1298C) in relation to colorectal adenoma r... | DisGeNET | Detail |
| No decrease in factor consumption was noted in patients with hemophilia having MTHFR A1298C mutation... | DisGeNET | Detail |
| Methylenetetrahydrofolate reductase A1298C genotypes are associated with the risks of acute lymphobl... | DisGeNET | Detail |
| Thus, A1298C polymorphism of MTHFR gene appears to be associated with the severity of carotid athero... | DisGeNET | Detail |
| Association of the A1298C polymorphism in MTHFR gene with ischemic stroke. | DisGeNET | Detail |
| Relationship between methylenetetrahydrofolate reductase C677T and A1298C genotypes and haplotypes a... | DisGeNET | Detail |
| The marginal association between the MTHFR A1298C polymorphisms and the susceptibility to cervical c... | DisGeNET | Detail |
| Effects of the C677T and A1298C polymorphisms of the MTHFR gene on the genetic predisposition for di... | DisGeNET | Detail |
| Because they have been described as strong risk factors for idiopathic recurrent pregnancy losses (R... | DisGeNET | Detail |
| The maternal methylenetetrahydrofolate reductase A1298C polymorphism was found to be an effect modif... | DisGeNET | Detail |
| A case-control study of 72 retinoblastoma cases and 98 cancer-free children controls was performed t... | DisGeNET | Detail |
| In this case-control study, we investigated the association between MTHFR C677T and A1298C, TYMS 5'-... | DisGeNET | Detail |
| A case-control study of 72 retinoblastoma cases and 98 cancer-free children controls was performed t... | DisGeNET | Detail |
| In conclusion, the presence of three or more polymorphic alleles for MTHFR C677T, MTHFR A1298C, MTR ... | DisGeNET | Detail |
| In this case-control study, we investigated the association between MTHFR C677T and A1298C, TYMS 5'-... | DisGeNET | Detail |
| In conclusion, the presence of three or more polymorphic alleles for MTHFR C677T, MTHFR A1298C, MTR ... | DisGeNET | Detail |
| The aim of the present study was to investigate the effect of polymorphisms C677T and A1298C in the ... | DisGeNET | Detail |
| A case-control study of 72 retinoblastoma cases and 98 cancer-free children controls was performed t... | DisGeNET | Detail |
| In this case-control study, we investigated the association between MTHFR C677T and A1298C, TYMS 5'-... | DisGeNET | Detail |
| In this case-control study, we investigated the association between MTHFR C677T and A1298C, TYMS 5'-... | DisGeNET | Detail |
| In conclusion, the presence of three or more polymorphic alleles for MTHFR C677T, MTHFR A1298C, MTR ... | DisGeNET | Detail |
| We performed a case-control association study to evaluate the association between common polymorphis... | DisGeNET | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- -
- dbSNP
- rs397507444 dbSNP
- Genome
- hg38
- Position
- chr1:11,794,407-11,794,407
- Variant Type
- snv
- Reference Allele
- T
- Alternative Allele
- G
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